PDK2

From Wikipedia, the free encyclopedia

Pyruvate dehydrogenase kinase, isozyme 2

PDB rendering based on 1jm6.

Available structures: 1jm6, 2btz, 2bu2, 2bu5, 2bu6, 2bu7, 2bu8

Identifiers

Symbol(s)

PDK2;

External IDs

OMIM: 602525 MGI: 1343087 HomoloGene: 68265

Gene ontology
Molecular Function:	• protein histidine kinase activity • [pyruvate dehydrogenase (lipoamide) kinase activity] • protein binding • ATP binding
Cellular Component:	• mitochondrion
Biological Process:	• carbohydrate metabolic process • glucose metabolic process • phosphorylation • peptidyl-histidine phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002611 (mRNA)
NP_002602 (protein)

XM_975730 (mRNA)
XP_980824 (protein)

Location

Chr 17: 45.53 - 45.54 Mb

Chr 11: 94.84 - 94.86 Mb

Pubmed search

[1]

[2]

Pyruvate dehydrogenase kinase, isozyme 2, also known as PDK2, is a human gene.^[1] It codes for an isozyme of pyruvate dehydrogenase kinase.

[edit] References

^ Entrez Gene: PDK2 pyruvate dehydrogenase kinase, isozyme 2.

[edit] Further reading

Sugden MC, Holness MJ (2003). "Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.". Am. J. Physiol. Endocrinol. Metab. 284 (5): E855–62. doi:10.1152/ajpendo.00526.2002. PMID 12676647.
Gudi R, Bowker-Kinley MM, Kedishvili NY, et al. (1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans.". J. Biol. Chem. 270 (48): 28989–94. PMID 7499431.
Kobayashi T, Cohen P (1999). "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.". Biochem. J. 339 ( Pt 2): 319–28. PMID 10191262.
Gold MR, Scheid MP, Santos L, et al. (1999). "The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase.". J. Immunol. 163 (4): 1894–905. PMID 10438924.
Baker JC, Yan X, Peng T, et al. (2000). "Marked differences between two isoforms of human pyruvate dehydrogenase kinase.". J. Biol. Chem. 275 (21): 15773–81. doi:10.1074/jbc.M909488199. PMID 10748134.
Steussy CN, Popov KM, Bowker-Kinley MM, et al. (2001). "Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase.". J. Biol. Chem. 276 (40): 37443–50. doi:10.1074/jbc.M104285200. PMID 11483605.
Kolobova E, Tuganova A, Boulatnikov I, Popov KM (2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.". Biochem. J. 358 (Pt 1): 69–77. PMID 11485553.
Korotchkina LG, Patel MS (2001). "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.". J. Biol. Chem. 276 (40): 37223–9. doi:10.1074/jbc.M103069200. PMID 11486000.
Peters SJ, Harris RA, Wu P, et al. (2002). "Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet.". Am. J. Physiol. Endocrinol. Metab. 281 (6): E1151–8. PMID 11701428.
Tuganova A, Boulatnikov I, Popov KM (2002). "Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.". Biochem. J. 366 (Pt 1): 129–36. doi:10.1042/BJ20020301. PMID 11978179.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Boulatnikov I, Popov KM (2003). "Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase.". Biochim. Biophys. Acta 1645 (2): 183–92. PMID 12573248.
Hiromasa Y, Roche TE (2003). "Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase.". J. Biol. Chem. 278 (36): 33681–93. doi:10.1074/jbc.M212733200. PMID 12816949.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Watt MJ, Heigenhauser GJ, LeBlanc PJ, et al. (2005). "Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise.". J. Appl. Physiol. 97 (4): 1261–7. doi:10.1152/japplphysiol.00132.2004. PMID 15169745.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bao H, Kasten SA, Yan X, Roche TE (2004). "Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.". Biochemistry 43 (42): 13432–41. doi:10.1021/bi049488x. PMID 15491150.
Bao H, Kasten SA, Yan X, et al. (2004). "Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.". Biochemistry 43 (42): 13442–51. doi:10.1021/bi0494875. PMID 15491151.
Abbot EL, McCormack JG, Reynet C, et al. (2005). "Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.". FEBS J. 272 (12): 3004–14. doi:10.1111/j.1742-4658.2005.04713.x. PMID 15955060.