PDGFD

From Wikipedia, the free encyclopedia

Platelet derived growth factor D

Identifiers

PDGFD; IEGF; MGC26867; MSTP036; SCDGF-B

External IDs

OMIM: 609673 MGI: 1919035 HomoloGene: 11875

Gene ontology
Molecular Function:	• growth factor activity
Cellular Component:	• membrane
Biological Process:	• regulation of progression through cell cycle • cell proliferation • regulation of peptidyl-tyrosine phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_025208 (mRNA)
NP_079484 (protein)

NM_027924 (mRNA)
NP_082200 (protein)

Location

Chr 11: 103.28 - 103.54 Mb

Chr 9: 6.17 - 6.38 Mb

Pubmed search

[1]

[2]

Platelet derived growth factor D, also known as PDGFD, is a human gene.^[1]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PDGFD platelet derived growth factor D.

[edit] Further reading

Hamada T, Ui-Tei K, Imaki J, Miyata Y (2001). "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein.". Biochem. Biophys. Res. Commun. 280 (3): 733-7. doi:10.1006/bbrc.2000.4187. PMID 11162582.
Bergsten E, Uutela M, Li X, et al. (2001). "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.". Nat. Cell Biol. 3 (5): 512-6. doi:10.1038/35074588. PMID 11331881.
LaRochelle WJ, Jeffers M, McDonald WF, et al. (2001). "PDGF-D, a new protease-activated growth factor.". Nat. Cell Biol. 3 (5): 517-21. doi:10.1038/35074593. PMID 11331882.
Uutela M, Laurén J, Bergsten E, et al. (2001). "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes.". Circulation 103 (18): 2242-7. PMID 11342471.
LaRochelle WJ, Jeffers M, Corvalan JR, et al. (2002). "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer.". Cancer Res. 62 (9): 2468-73. PMID 11980634.
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185-95. PMID 12107412.
Changsirikulchai S, Hudkins KL, Goodpaster TA, et al. (2003). "Platelet-derived growth factor-D expression in developing and mature human kidneys.". Kidney Int. 62 (6): 2043-54. doi:10.1046/j.1523-1755.2002.00662.x. PMID 12427128.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Taneda S, Hudkins KL, Topouzis S, et al. (2004). "Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury.". J. Am. Soc. Nephrol. 14 (10): 2544-55. PMID 14514732.
Uutela M, Wirzenius M, Paavonen K, et al. (2004). "PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.". Blood 104 (10): 3198-204. doi:10.1182/blood-2004-04-1485. PMID 15271796.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ray S, Gao C, Wyatt K, et al. (2005). "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation.". J. Biol. Chem. 280 (9): 8494-502. doi:10.1074/jbc.M413570200. PMID 15611105.
Ustach CV, Kim HR (2005). "Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells.". Mol. Cell. Biol. 25 (14): 6279-88. doi:10.1128/MCB.25.14.6279-6288.2005. PMID 15988036.
Liu MY, Eyries M, Zhang C, et al. (2006). "Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1.". Blood 107 (6): 2322-9. doi:10.1182/blood-2005-06-2377. PMID 16189269.