PDGFB

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Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
PDB rendering based on 1pdg.
Available structures: 1pdg
Identifiers
Symbol(s)	PDGFB; FLJ12858; PDGF2; SIS; SSV; c-sis
External IDs	OMIM: 190040 MGI: 97528 HomoloGene: 74303
Gene ontology Molecular Function: • platelet-derived growth factor receptor binding • growth factor activity Cellular Component: • extracellular region • membrane Biological Process: • regulation of progression through cell cycle • substrate-bound cell migration • cell proliferation • response to wounding • cell projection biogenesis • actin cytoskeleton organization and biogenesis • regulation of peptidyl-tyrosine phosphorylation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5155	18591
Ensembl	ENSG00000100311	ENSMUSG00000000489
Uniprot	P01127	Q549C6
Refseq	NM_002608 (mRNA) NP_002599 (protein)	XM_985718 (mRNA) XP_990812 (protein)
Location	Chr 22: 37.95 - 37.97 Mb	Chr 15: 79.82 - 79.84 Mb
Pubmed search	[1]	[2]

Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog), also known as PDGFB, is a human gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.^[1]

[edit] See also

• Platelet-derived growth factor

[edit] References

[edit] Further reading

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