PDE9A

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Phosphodiesterase 9A
PDB rendering based on 2hd1.
Available structures: 2hd1
Identifiers
Symbol(s) PDE9A; HSPDE9A2
External IDs OMIM: 602973 MGI: 1277179 HomoloGene: 31100
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5152 18585
Ensembl ENSG00000160191 ENSMUSG00000041119
Uniprot O76083 Q3THT7
Refseq NM_001001567 (mRNA)
NP_001001567 (protein)		 NM_008804 (mRNA)
NP_032830 (protein)
Location Chr 21: 42.95 - 43.07 Mb Chr 17: 31.11 - 31.21 Mb
Pubmed search [1] [2]

Phosphodiesterase 9A, also known as PDE9A, is a human gene.[1]

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: PDE9A phosphodiesterase 9A.

[edit] Further reading

  • Fisher DA, Smith JF, Pillar JS, et al. (1998). "Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase.". J. Biol. Chem. 273 (25): 15559–64. PMID 9624146. 
  • Guipponi M, Scott HS, Kudoh J, et al. (1998). "Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence.". Hum. Genet. 103 (4): 386–92. PMID 9856478. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Rentero C, Monfort A, Puigdomènech P (2003). "Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene.". Biochem. Biophys. Res. Commun. 301 (3): 686–92. PMID 12565835. 
  • Wang P, Wu P, Egan RW, Billah MM (2003). "Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants.". Gene 314: 15–27. PMID 14527714. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Huai Q, Wang H, Zhang W, et al. (2004). "Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding.". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9624–9. doi:10.1073/pnas.0401120101. PMID 15210993. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMID 16780588. 
  • Rentero C, Puigdomènech P (2007). "Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene.". BMC Mol. Biol. 7: 39. doi:10.1186/1471-2199-7-39. PMID 17090334. 
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