PDE8A

From Wikipedia, the free encyclopedia

Phosphodiesterase 8A

Identifiers

PDE8A; FLJ16150; HsT19550

External IDs

OMIM: 602972 MGI: 1277116 HomoloGene: 1957

Gene ontology
Molecular Function:	• two-component response regulator activity • magnesium ion binding • 3',5'-cyclic-AMP phosphodiesterase activity • hydrolase activity • manganese ion binding
Cellular Component:	• cellular_component
Biological Process:	• two-component signal transduction system (phosphorelay) • regulation of transcription, DNA-dependent • cyclic nucleotide metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_173455 (mRNA)
NP_775657 (protein)

XM_983775 (mRNA)
XP_988869 (protein)

Location

Chr 15: 83.32 - 83.48 Mb

Chr 7: 81.09 - 81.21 Mb

Pubmed search

[1]

[2]

Phosphodiesterase 8A, also known as PDE8A, is a human gene.^[1]

[edit] References

^ Entrez Gene: PDE8A phosphodiesterase 8A.

[edit] Further reading

Bass BL (2002). "RNA editing by adenosine deaminases that act on RNA.". Annu. Rev. Biochem. 71: 817–46. doi:10.1146/annurev.biochem.71.110601.135501. PMID 12045112.
Fisher DA, Smith JF, Pillar JS, et al. (1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.". Biochem. Biophys. Res. Commun. 246 (3): 570–7. doi:10.1006/bbrc.1998.8684. PMID 9618252.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Glavas NA, Ostenson C, Schaefer JB, et al. (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–24. doi:10.1073/pnas.101131098. PMID 11371644.
Wang P, Wu P, Egan RW, Billah MM (2002). "Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution.". Gene 280 (1-2): 183–94. PMID 11738832.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.". Cell. Signal. 15 (6): 565–74. PMID 12681444.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wu P, Wang P (2005). "Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (51): 17634–9. doi:10.1073/pnas.0407649101. PMID 15596729.