PDE2A

From Wikipedia, the free encyclopedia

Phosphodiesterase 2A, cGMP-stimulated

PDB rendering based on 1mc0.

Available structures: 1mc0, 1z1l

Identifiers

Symbol(s)

PDE2A; PDE2A1; PED2A4

External IDs

OMIM: 602658 MGI: 2446107 HomoloGene: 1952

Gene ontology
Molecular Function:	• catalytic activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • hydrolase activity
Cellular Component:	• membrane
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002599 (mRNA)
NP_002590 (protein)

NM_001008548 (mRNA)
NP_001008548 (protein)

Location

Chr 11: 71.96 - 72.06 Mb

Chr 7: 101.3 - 101.39 Mb

Pubmed search

[1]

[2]

Phosphodiesterase 2A, cGMP-stimulated, also known as PDE2A, is a human gene.^[1]

[edit] References

^ Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated.

[edit] Further reading

Seybold J, Thomas D, Witzenrath M, et al. (2005). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability.". Blood 105 (9): 3569-76. doi:10.1182/blood-2004-07-2729. PMID 15650061.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Martinez SE, Wu AY, Glavas NA, et al. (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260-5. doi:10.1073/pnas.192374899. PMID 12271124.
Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases.". Thromb. Haemost. 87 (5): 873-9. PMID 12038792.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483-91. doi:10.1096/fj.00-0354com. PMID 11156964.
Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells.". J. Histochem. Cytochem. 47 (7): 895-906. PMID 10375378.
Rosman GJ, Martins TJ, Sonnenburg WK, et al. (1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase.". Gene 191 (1): 89-95. PMID 9210593.