PDE1B

From Wikipedia, the free encyclopedia

Phosphodiesterase 1B, calmodulin-dependent

PDB rendering based on 1taz.

Available structures: 1taz

Identifiers

Symbol(s)

PDE1B; PDE1B1; PDES1B

External IDs

OMIM: 171891 MGI: 97523 HomoloGene: 37370

Gene ontology
Molecular Function:	• catalytic activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity • calmodulin binding • hydrolase activity
Biological Process:	• apoptosis • signal transduction • locomotory behavior • visual learning

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000924 (mRNA)
NP_000915 (protein)

NM_008800 (mRNA)
NP_032826 (protein)

Location

Chr 12: 53.23 - 53.26 Mb

Chr 15: 103.33 - 103.36 Mb

Pubmed search

[1]

[2]

Phosphodiesterase 1B, calmodulin-dependent, also known as PDE1B, is a human gene.^[1]

[edit] References

^ Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent.

[edit] Further reading

Repaske DR, Swinnen JV, Jin SL, et al. (1992). "A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase.". J. Biol. Chem. 267 (26): 18683–8. PMID 1326532.
Jiang X, Li J, Paskind M, Epstein PM (1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells.". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 11236–41. PMID 8855339.
Spence S, Rena G, Sullivan M, et al. (1997). "Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase.". Biochem. J. 321 ( Pt 1): 157–63. PMID 9003415.
Yu J, Wolda SL, Frazier AL, et al. (1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1.". Cell. Signal. 9 (7): 519–29. PMID 9419816.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants.". Cell. Signal. 14 (1): 53–60. PMID 11747989.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bender AT, Ostenson CL, Wang EH, Beavo JA (2005). "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation.". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 497–502. doi:10.1073/pnas.0408535102. PMID 15625104.
Bender AT, Beavo JA (2006). "PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte.". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 460–5. doi:10.1073/pnas.0509972102. PMID 16407168.