PDE11A

From Wikipedia, the free encyclopedia

Phosphodiesterase 11A

Identifiers

PDE11A; FLJ23693; MGC133355; MGC133356

External IDs

OMIM: 604961 MGI: 3036251 HomoloGene: 56763

Gene ontology
Molecular Function:	• hydrolase activity • metal ion binding • 3',5'-cyclic-GMP phosphodiesterase activity
Cellular Component:	• cellular_component
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001077196 (mRNA)
NP_001070664 (protein)

XM_001002911 (mRNA)
XP_001002911 (protein)

Location

Chr 2: 178.2 - 178.68 Mb

n/a

Pubmed search

[1]

[2]

Phosphodiesterase 11A, also known as PDE11A, is a human gene.^[1]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PDE11A phosphodiesterase 11A.

[edit] Further reading

Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases.". Mol. Pharmacol. 46 (3): 399–405. PMID 7935318.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Fawcett L, Baxendale R, Stacey P, et al. (2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMID 10725373.
Yuasa K, Kotera J, Fujishige K, et al. (2000). "Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression.". J. Biol. Chem. 275 (40): 31469–79. doi:10.1074/jbc.M003041200. PMID 10906126.
Hetman JM, Robas N, Baxendale R, et al. (2001). "Cloning and characterization of two splice variants of human phosphodiesterase 11A.". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12891–5. doi:10.1073/pnas.200355397. PMID 11050148.
Yuasa K, Kanoh Y, Okumura K, Omori K (2001). "Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains.". Eur. J. Biochem. 268 (1): 168–78. PMID 11121118.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants.". Eur. J. Biochem. 268 (16): 4440–8. PMID 11502204.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Weeks JL, Zoraghi R, Beasley A, et al. (2005). "High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients.". Int. J. Impot. Res. 17 (1): 5–9. doi:10.1038/sj.ijir.3901283. PMID 15538396.
Loughney K, Taylor J, Florio VA (2005). "3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.". Int. J. Impot. Res. 17 (4): 320–5. doi:10.1038/sj.ijir.3901317. PMID 15800651.
Wayman C, Phillips S, Lunny C, et al. (2005). "Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology.". Int. J. Impot. Res. 17 (3): 216–23. doi:10.1038/sj.ijir.3901307. PMID 15800654.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
D'Andrea MR, Qiu Y, Haynes-Johnson D, et al. (2005). "Expression of PDE11A in normal and malignant human tissues.". J. Histochem. Cytochem. 53 (7): 895–903. doi:10.1369/jhc.5A6625.2005. PMID 15995148.
Francis SH (2005). "Phosphodiesterase 11 (PDE11): is it a player in human testicular function?". Int. J. Impot. Res. 17 (5): 467–8. doi:10.1038/sj.ijir.3901377. PMID 16079899.
Gross-Langenhoff M, Hofbauer K, Weber J, et al. (2006). "cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11.". J. Biol. Chem. 281 (5): 2841–6. doi:10.1074/jbc.M511468200. PMID 16330539.
Horvath A, Boikos S, Giatzakis C, et al. (2006). "A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.". Nat. Genet. 38 (7): 794–800. doi:10.1038/ng1809. PMID 16767104.
Wong ML, Whelan F, Deloukas P, et al. (2006). "Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.". Proc. Natl. Acad. Sci. U.S.A. 103 (41): 15124–9. doi:10.1073/pnas.0602795103. PMID 17008408.