PDE10A

From Wikipedia, the free encyclopedia


Phosphodiesterase 10A
PDB rendering based on 2o8h.
Available structures: 2o8h, 2oun, 2oup, 2ouq, 2our, 2ous, 2ouu, 2ouv, 2ouy, 2ovv, 2ovy
Identifiers
Symbol(s) PDE10A; FLJ11894; HSPDE10A
External IDs OMIM: 610652 MGI: 1345143 HomoloGene: 4852
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10846 23984
Ensembl ENSG00000112541 ENSMUSG00000023868
Uniprot Q9Y233 n/a
Refseq NM_006661 (mRNA)
NP_006652 (protein)		 NM_011866 (mRNA)
NP_035996 (protein)
Location Chr 6: 165.66 - 166 Mb Chr 17: 8.64 - 8.82 Mb
Pubmed search [1] [2]

Phosphodiesterase 10A, also known as PDE10A, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: PDE10A phosphodiesterase 10A.

[edit] Further reading

  • Fujishige K, Kotera J, Michibata H, et al. (1999). "Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).". J. Biol. Chem. 274 (26): 18438–45. PMID 10373451. 
  • Loughney K, Snyder PB, Uher L, et al. (1999). "Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase.". Gene 234 (1): 109–17. PMID 10393245. 
  • Kotera J, Fujishige K, Yuasa K, Omori K (1999). "Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP.". Biochem. Biophys. Res. Commun. 261 (3): 551–7. doi:10.1006/bbrc.1999.1013. PMID 10441464. 
  • Fujishige K, Kotera J, Yuasa K, Omori K (2000). "The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains.". Eur. J. Biochem. 267 (19): 5943–51. PMID 10998054. 
  • Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. 
  • Frame M, Wan KF, Tate R, et al. (2001). "The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3.". Cell. Signal. 13 (10): 735–41. PMID 11602184. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Gross-Langenhoff M, Hofbauer K, Weber J, et al. (2006). "cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11.". J. Biol. Chem. 281 (5): 2841–6. doi:10.1074/jbc.M511468200. PMID 16330539. 
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