PDCD4

From Wikipedia, the free encyclopedia

Programmed cell death 4 (neoplastic transformation inhibitor)

PDB rendering based on 2ggf.

Available structures: 2ggf, 2hm8, 2iol, 2ion, 2ios, 2nsz

Identifiers

Symbol(s)

PDCD4; H731; MGC33046; MGC33047

External IDs

OMIM: 608610 MGI: 107490 HomoloGene: 7879

Gene ontology
Molecular Function:	• RNA binding • protein binding
Cellular Component:	• nucleus • cytoplasm • cytosol
Biological Process:	• apoptosis • cell cycle • cell aging • negative regulation of transcription • negative regulation of JNK activity • negative regulation of progression through cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_014456 (mRNA)
NP_055271 (protein)

NM_011050 (mRNA)
NP_035180 (protein)

Location

Chr 10: 112.62 - 112.65 Mb

n/a

Pubmed search

[1]

[2]

Programmed cell death 4 (neoplastic transformation inhibitor), also known as PDCD4, is a human gene.^[1]

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: PDCD4 programmed cell death 4 (neoplastic transformation inhibitor).

[edit] Further reading

Göke R, Gregel C, Göke A, et al. (2004). "Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells.". Ann. N. Y. Acad. Sci. 1014: 220-1. PMID 15153438.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Shibahara K, Asano M, Ishida Y, et al. (1996). "Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.". Gene 166 (2): 297-301. PMID 8543179.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Azzoni L, Zatsepina O, Abebe B, et al. (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells.". J. Immunol. 161 (7): 3493-500. PMID 9759869.
Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z (2000). "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody.". Pathol. Int. 49 (12): 1067-77. PMID 10632927.
Soejima H, Miyoshi O, Yoshinaga H, et al. (2000). "Assignment of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization.". Cytogenet. Cell Genet. 87 (1-2): 113-4. PMID 10640828.
Kang MJ, Ahn HS, Lee JY, et al. (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts.". Biochem. Biophys. Res. Commun. 293 (1): 617-21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chen Y, Knösel T, Kristiansen G, et al. (2003). "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis.". J. Pathol. 200 (5): 640-6. doi:10.1002/path.1378. PMID 12898601.
Yang HS, Cho MH, Zakowicz H, et al. (2004). "A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.". Mol. Cell. Biol. 24 (9): 3894-906. PMID 15082783.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:10.1021/ac035352d. PMID 15144186.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Göke R, Barth P, Schmidt A, et al. (2004). "Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).". Am. J. Physiol., Cell Physiol. 287 (6): C1541-6. doi:10.1152/ajpcell.00025.2004. PMID 15317660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Palamarchuk A, Efanov A, Maximov V, et al. (2006). "Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.". Cancer Res. 65 (24): 11282-6. doi:10.1158/0008-5472.CAN-05-3469. PMID 16357133.
Yang HS, Matthews CP, Clair T, et al. (2006). "Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.". Mol. Cell. Biol. 26 (4): 1297-306. doi:10.1128/MCB.26.4.1297-1306.2006. PMID 16449643.