PDCD2

From Wikipedia, the free encyclopedia

Programmed cell death 2

Identifiers

PDCD2; MGC12347; RP8; ZMYND7

External IDs

OMIM: 600866 MGI: 104643 HomoloGene: 1951

Gene ontology
Molecular Function:	• DNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002598 (mRNA)
NP_002589 (protein)

NM_008799 (mRNA)
NP_032825 (protein)

Location

Chr 6: 170.73 - 170.74 Mb

Chr 17: 15.23 - 15.23 Mb

Pubmed search

[1]

[2]

Programmed cell death 2, also known as PDCD2, is a human gene.^[1]

This gene encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Two transcripts encoding different proteins have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: PDCD2 programmed cell death 2.

[edit] Further reading

Kawakami T, Furukawa Y, Sudo K, et al. (1995). "Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death.". Cytogenet. Cell Genet. 71 (1): 41–3. PMID 7606924.
Baron BW, Anastasi J, Thirman MJ, et al. (2002). "The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2860–5. doi:10.1073/pnas.042702599. PMID 11854457.
Scarr RB, Sharp PA (2002). "PDCD2 is a negative regulator of HCF-1 (C1).". Oncogene 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. PMID 12149646.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chen Q, Qian K, Yan C (2006). "Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells.". Mol. Cell. Biochem. 280 (1-2): 185–91. doi:10.1007/s11010-005-8910-z. PMID 16311922.
Baron BW, Zeleznik-Le N, Baron MJ, et al. (2007). "Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.". Proc. Natl. Acad. Sci. U.S.A. 104 (18): 7449–54. doi:10.1073/pnas.0701770104. PMID 17468402.