PCSK4

From Wikipedia, the free encyclopedia

Proprotein convertase subtilisin/kexin type 4

Identifiers

PCSK4; PC4; DKFZp434B217; MGC34749; SPC5

External IDs

OMIM: 600487 MGI: 97514 HomoloGene: 22495

Gene ontology
Molecular Function:	• subtilase activity • peptidase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• proteolysis

Orthologs

Human

Mouse

Refseq

NM_017573 (mRNA)
NP_060043 (protein)

NM_008793 (mRNA)
NP_032819 (protein)

Location

Chr 19: 1.43 - 1.44 Mb

Chr 10: 79.72 - 79.73 Mb

Pubmed search

[1]

[2]

Proprotein convertase subtilisin/kexin type 4, also known as PCSK4, is a human gene.^[1]

[edit] References

^ Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4.

[edit] Further reading

Seidah NG, Chrétien M, Day R (1995). "The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.". Biochimie 76 (3-4): 197–209. PMID 7819324.
Bassi DE, Mahloogi H, Klein-Szanto AJ (2000). "The proprotein convertases furin and PACE4 play a significant role in tumor progression.". Mol. Carcinog. 28 (2): 63–9. PMID 10900462.
Mbikay M, Seidah NG, Chrétien M, Simpson EM (1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.". Genomics 26 (1): 123–9. PMID 7782070.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. PMID 9482861.
Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III.". Mol. Cell 1 (5): 749–57. PMID 9660958.
Li M, Mbikay M, Nakayama K, et al. (2001). "Prohormone convertase PC4 processes the precursor of PACAP in the testis.". Ann. N. Y. Acad. Sci. 921: 333–9. PMID 11193847.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Qiu Q, Basak A, Mbikay M, et al. (2005). "Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.". Proc. Natl. Acad. Sci. U.S.A. 102 (31): 11047–52. doi:10.1073/pnas.0502357102. PMID 16040806.