PCLO

From Wikipedia, the free encyclopedia

Piccolo (presynaptic cytomatrix protein)

Identifiers

PCLO; ACZ; DKFZp779G1236

External IDs

OMIM: 604918 MGI: 1349390 HomoloGene: 69111

Gene ontology
Molecular Function:	• transporter activity • calcium ion binding • protein binding • profilin binding • calcium-dependent phospholipid binding • zinc ion binding • metal ion binding
Cellular Component:	• cytoskeleton • synaptic vesicle • membrane • synapse
Biological Process:	• transport • cytoskeleton organization and biogenesis • synaptic vesicle targeting

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_929946 (mRNA)
XP_935039 (protein)

NM_011995 (mRNA)
NP_036125 (protein)

Location

Chr 7: 82.23 - 82.63 Mb

Chr 5: 14.52 - 14.86 Mb

Pubmed search

[1]

[2]

Piccolo (presynaptic cytomatrix protein), also known as PCLO, is a human gene.^[1]

Synaptic vesicles dock and fuse in the active zone of the plasma membrane at chemical synapses. The presynaptic cytoskeletal matrix (PCM), which is associated with the active zone and is situated between synaptic vesicles, is thought to be involved in maintaining the neurotransmitter release site in register with the postsynaptic reception apparatus. The cycling of synaptic vesicles is a multistep process involving a number of proteins (see MIM 603215). Among the components of the PCM that orchestrate these events are Bassoon (BSN; MIM 604020), RIM (RBBP8; MIM 604124), Oboe, and Piccolo (PCLO).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PCLO piccolo (presynaptic cytomatrix protein).

[edit] Further reading

Cases-Langhoff C, Voss B, Garner AM, et al. (1996). "Piccolo, a novel 420 kDa protein associated with the presynaptic cytomatrix.". Eur. J. Cell Biol. 69 (3): 214-23. PMID 8900486.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31-9. PMID 9628581.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Wang X, Kibschull M, Laue MM, et al. (1999). "Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.". J. Cell Biol. 147 (1): 151-62. PMID 10508862.
Fenster SD, Chung WJ, Zhai R, et al. (2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon.". Neuron 25 (1): 203-14. PMID 10707984.
Fenster SD, Garner CC (2002). "Gene structure and genetic localization of the PCLO gene encoding the presynaptic active zone protein Piccolo.". Int. J. Dev. Neurosci. 20 (3-5): 161-71. PMID 12175852.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Takao-Rikitsu E, Mochida S, Inoue E, et al. (2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.". J. Cell Biol. 164 (2): 301-11. doi:10.1083/jcb.200307101. PMID 14734538.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.