PCLKC

From Wikipedia, the free encyclopedia

Protocadherin LKC

Identifiers

PCLKC; FLJ20124; FLJ20383; MGC163154

External IDs

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• cell adhesion • homophilic cell adhesion • negative regulation of cell growth

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_017675 (mRNA)
NP_060145 (protein)

XM_983653 (mRNA)
XP_988747 (protein)

Location

Chr 5: 175.91 - 175.96 Mb

Chr 13: 54.71 - 54.75 Mb

Pubmed search

[1]

[2]

Protocadherin LKC, also known as PCLKC, is a human gene.^[1]

This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. The kidney-expressed gene product has a signal peptide, nine cadherin repeat domains and a unique cytoplasmic region. This protocadherin represents a new candidate for tumor suppression.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCLKC protocadherin LKC.

[edit] Further reading

Suzuki ST (2000). "Recent progress in protocadherin research.". Exp. Cell Res. 261 (1): 13-8. doi:10.1006/excr.2000.5039. PMID 11082270.
Yang LY, Wang W, Peng JX, et al. (2005). "Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma.". World J. Gastroenterol. 10 (24): 3569-73. PMID 15534908.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Okazaki N, Takahashi N, Kojima S, et al. (2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.". Carcinogenesis 23 (7): 1139-48. PMID 12117771.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807-28. PMID 8889549.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.