PCGF2

From Wikipedia, the free encyclopedia

Polycomb group ring finger 2

PDB rendering based on 2h0d.

Available structures: 2h0d

Identifiers

Symbol(s)

PCGF2; MEL-18; MGC10545; RNF110; ZNF144

External IDs

OMIM: 600346 MGI: 99161 HomoloGene: 5174

Gene ontology
Molecular Function:	• chromatin binding • transcription factor activity • ubiquitin-protein ligase activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• sex chromatin • nucleus • nuclear body • PcG protein complex
Biological Process:	• transcription • regulation of transcription, DNA-dependent • anterior/posterior pattern formation • histone acetylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007144 (mRNA)
NP_009075 (protein)

NM_009545 (mRNA)
NP_033571 (protein)

Location

Chr 17: 34.14 - 34.16 Mb

Chr 11: 97.51 - 97.52 Mb

Pubmed search

[1]

[2]

Polycomb group ring finger 2, also known as PCGF2, is a human gene.^[1]

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCGF2 polycomb group ring finger 2.

[edit] Further reading

Ishida A, Asano H, Hasegawa M, et al. (1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif.". Gene 129 (2): 249-55. PMID 8325509.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Kimura M, Koseki Y, Yamashita M, et al. (2001). "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene.". Immunity 15 (2): 275-87. PMID 11520462.
Miyazaki K, Inoue H, Onai N, et al. (2002). "Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18.". Immunol. Lett. 80 (2): 139-43. PMID 11750047.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070-8. PMID 12167701.
Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.". Development 129 (18): 4171-83. PMID 12183370.
Matsuo F, Yano K, Saito H, et al. (2002). "Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines.". Breast Cancer 9 (1): 33-8. PMID 12196719.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Silva J, García JM, Peña C, et al. (2007). "Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas.". Clin. Cancer Res. 12 (23): 6929-36. doi:10.1158/1078-0432.CCR-06-0788. PMID 17145810.
Guo WJ, Datta S, Band V, Dimri GP (2007). "Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins.". Mol. Biol. Cell 18 (2): 536-46. doi:10.1091/mbc.E06-05-0447. PMID 17151361.
Wiederschain D, Chen L, Johnson B, et al. (2007). "Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis.". Mol. Cell. Biol. 27 (13): 4968-79. doi:10.1128/MCB.02244-06. PMID 17452456.
Guo WJ, Zeng MS, Yadav A, et al. (2007). "Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells.". Cancer Res. 67 (11): 5083-9. doi:10.1158/0008-5472.CAN-06-4368. PMID 17545584.
Szafranski K, Schindler S, Taudien S, et al.. "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.