PCDHA4

From Wikipedia, the free encyclopedia

Protocadherin alpha 4

PDB rendering based on 1wuz.

Available structures: 1wuz

Identifiers

Symbol(s)

PCDHA4; CNR1; CNRN1; CRNR1; MGC138307; MGC142169; PCDH-ALPHA4

External IDs

OMIM: 606310 MGI: 1298406 HomoloGene: 75097

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cell adhesion • homophilic cell adhesion • nervous system development

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_018907 (mRNA)
NP_061730 (protein)

XM_991107 (mRNA)
XP_996201 (protein)

Location

Chr 5: 140.17 - 140.17 Mb

n/a

Pubmed search

[1]

[2]

Protocadherin alpha 4, also known as PCDHA4, is a human gene.^[1]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCDHA4 protocadherin alpha 4.

[edit] Further reading

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169–80. PMID 10817752.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes.". Cell 97 (6): 779–90. PMID 10380929.
Senzaki K, Ogawa M, Yagi T (2000). "Proteins of the CNR family are multiple receptors for Reelin.". Cell 99 (6): 635–47. PMID 10612399.
Sugino H, Hamada S, Yasuda R, et al. (2000). "Genomic organization of the family of CNR cadherin genes in mice and humans.". Genomics 63 (1): 75–87. doi:10.1006/geno.1999.6066. PMID 10662547.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMID 10716726.
Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMID 11230163.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.