PCDH8

From Wikipedia, the free encyclopedia

Protocadherin 8

Identifiers

PCDH8; ARCADLIN; PAPC

External IDs

OMIM: 603580 MGI: 1306800 HomoloGene: 1943

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• somitogenesis • cell adhesion • homophilic cell adhesion • cell-cell signaling • morphogenesis of embryonic epithelium

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_002590 (mRNA)
NP_002581 (protein)

NM_001042726 (mRNA)
NP_001036191 (protein)

Location

Chr 13: 52.32 - 52.32 Mb

Chr 14: 78.5 - 78.51 Mb

Pubmed search

[1]

[2]

Protocadherin 8, also known as PCDH8, is a human gene.^[1]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCDH8 protocadherin 8.

[edit] Further reading

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169-80. PMID 10817752.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551-72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Strehl S, LaSalle JM, Lalande M (1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary.". Mol. Cell. Biol. 17 (10): 6157-66. PMID 9315676.
Strehl S, Glatt K, Liu QM, et al. (1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14.". Genomics 53 (1): 81-9. doi:10.1006/geno.1998.5467. PMID 9787079.
Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes.". Cell 97 (6): 779-90. PMID 10380929.
Yamagata K, Andreasson KI, Sugiura H, et al. (1999). "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation.". J. Biol. Chem. 274 (27): 19473-1979. PMID 10383464.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124-9. doi:10.1073/pnas.060027397. PMID 10716726.
Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.". Genome Res. 11 (3): 389-404. doi:10.1101/gr.167301. PMID 11230163.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bray NJ, Kirov G, Owen RJ, et al. (2003). "Screening the human protocadherin 8 (PCDH8) gene in schizophrenia.". Genes Brain Behav. 1 (3): 187-91. PMID 12884975.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.