PCDH18

From Wikipedia, the free encyclopedia

Protocadherin 18

Identifiers

PCDH18; DKFZP434B0923; KIAA1562; PCDH68L

External IDs

OMIM: 608287 MGI: 1920423 HomoloGene: 10389

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cell adhesion • homophilic cell adhesion • brain development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_019035 (mRNA)
NP_061908 (protein)

NM_130448 (mRNA)
NP_569715 (protein)

Location

Chr 4: 138.66 - 138.67 Mb

Chr 3: 49.84 - 49.85 Mb

Pubmed search

[1]

[2]

Protocadherin 18, also known as PCDH18, is a human gene.^[1]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCDH18 protocadherin 18.

[edit] Further reading

Suzuki ST (2000). "Recent progress in protocadherin research.". Exp. Cell Res. 261 (1): 13-8. doi:10.1006/excr.2000.5039. PMID 11082270.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551-72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169-80. PMID 10817752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Homayouni R, Rice DS, Curran T (2002). "Disabled-1 interacts with a novel developmentally regulated protocadherin.". Biochem. Biophys. Res. Commun. 289 (2): 539-47. doi:10.1006/bbrc.2001.5998. PMID 11716507.
Wolverton T, Lalande M (2001). "Identification and characterization of three members of a novel subclass of protocadherins.". Genomics 76 (1-3): 66-72. doi:10.1006/geno.2001.6592. PMID 11549318.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124-9. doi:10.1073/pnas.060027397. PMID 10716726.