PCDH17

From Wikipedia, the free encyclopedia

Protocadherin 17

Identifiers

PCDH17; PCDH68; PCH68

External IDs

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• cell adhesion • homophilic cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001040429 (mRNA)
NP_001035519 (protein)

NM_001013753 (mRNA)
NP_001013775 (protein)

Location

Chr 13: 57.1 - 57.2 Mb

Chr 14: 83.25 - 83.34 Mb

Pubmed search

[1]

[2]

Protocadherin 17, also known as PCDH17, is a human gene.^[1]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCDH17 protocadherin 17.

[edit] Further reading

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169-80. PMID 10817752.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551-72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Suzuki ST (2000). "Recent progress in protocadherin research.". Exp. Cell Res. 261 (1): 13-8. doi:10.1006/excr.2000.5039. PMID 11082270.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124-9. doi:10.1073/pnas.060027397. PMID 10716726.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Szafranski K, Schindler S, Taudien S, et al.. "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.