PCBP3

From Wikipedia, the free encyclopedia

Poly(rC) binding protein 3

Identifiers

PCBP3; ALPHA-CP3

External IDs

OMIM: 608502 MGI: 1890470 HomoloGene: 23233

Gene ontology
Molecular Function:	• DNA binding • RNA binding
Cellular Component:	• ribonucleoprotein complex
Biological Process:	• mRNA metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020528 (mRNA)
NP_065389 (protein)

NM_021568 (mRNA)
NP_067543 (protein)

Location

Chr 21: 46.14 - 46.19 Mb

Chr 10: 76.21 - 76.24 Mb

Pubmed search

[1]

[2]

Poly(rC) binding protein 3, also known as PCBP3, is a human gene.^[1]

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple polyadenylation sites exist for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCBP3 poly(rC) binding protein 3.

[edit] Further reading

Makeyev AV, Liebhaber SA (2002). "The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms.". RNA 8 (3): 265–78. PMID 12003487.
Kiledjian M, Wang X, Liebhaber SA (1995). "Identification of two KH domain proteins in the alpha-globin mRNP stability complex.". EMBO J. 14 (17): 4357–64. PMID 7556077.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Makeyev AV, Liebhaber SA (2000). "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins.". Genomics 67 (3): 301–16. doi:10.1006/geno.2000.6244. PMID 10936052.
Makeyev AV, Eastmond DL, Liebhaber SA (2002). "Targeting a KH-domain protein with RNA decoys.". RNA 8 (9): 1160–73. PMID 12358435.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chkheidze AN, Liebhaber SA (2003). "A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins.". Mol. Cell. Biol. 23 (23): 8405–15. PMID 14612387.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMID 16780588.