PCAF

From Wikipedia, the free encyclopedia


P300/CBP-associated factor
PDB rendering based on 1cm0.
Available structures: 1cm0, 1jm4, 1n72, 1wug, 1wum, 1zs5
Identifiers
Symbol(s) PCAF; P; CAF; P/CAF
External IDs OMIM: 602303 MGI: 1343094 HomoloGene: 20834
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8850 18519
Ensembl ENSG00000114166 ENSMUSG00000000708
Uniprot Q92831 n/a
Refseq XM_001130666 (mRNA)
XP_001130666 (protein)		 XM_001003318 (mRNA)
XP_001003318 (protein)
Location Chr 3: 20.06 - 20.17 Mb Chr 17: 53.03 - 53.14 Mb
Pubmed search [1] [2]

P300/CBP-associated factor, also known as PCAF, is a human gene and trancriptional coactivator associated with p53.

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: PCAF p300/CBP-associated factor.

[edit] Further reading

  • Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator.". IUBMB Life 51 (3): 175–81. PMID 11547919. 
  • Ott M, Dorr A, Hetzer-Egger C, et al. (2004). "Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation.". Novartis Found. Symp. 259: 182–93; discussion 193–6, 223–5. PMID 15171254. 
  • Liou LY, Herrmann CH, Rice AP (2005). "HIV-1 infection and regulation of Tat function in macrophages.". Int. J. Biochem. Cell Biol. 36 (9): 1767–75. doi:10.1016/j.biocel.2004.02.018. PMID 15183343. 
  • Gibellini D, Vitone F, Schiavone P, Re MC (2005). "HIV-1 tat protein and cell proliferation and survival: a brief review.". New Microbiol. 28 (2): 95–109. PMID 16035254. 
  • Hetzer C, Dormeyer W, Schnölzer M, Ott M (2006). "Decoding Tat: the biology of HIV Tat posttranslational modifications.". Microbes Infect. 7 (13): 1364–9. doi:10.1016/j.micinf.2005.06.003. PMID 16046164. 
  • Peruzzi F (2006). "The multiple functions of HIV-1 Tat: proliferation versus apoptosis.". Front. Biosci. 11: 708–17. PMID 16146763. 
  • Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention.". Med Res Rev 26 (5): 595–625. doi:10.1002/med.20081. PMID 16838299. 
  • Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current drug targets 7 (12): 1595–606. PMID 17168834. 
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151. 
  • Yang XJ, Ogryzko VV, Nishikawa J, et al. (1996). "A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.". Nature 382 (6589): 319–24. doi:10.1038/382319a0. PMID 8684459. 
  • Ogryzko VV, Schiltz RL, Russanova V, et al. (1997). "The transcriptional coactivators p300 and CBP are histone acetyltransferases.". Cell 87 (5): 953–9. PMID 8945521. 
  • Jenster G, Spencer TE, Burcin MM, et al. (1997). "Steroid receptor induction of gene transcription: a two-step model.". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 7879–84. PMID 9223281. 
  • Chen H, Lin RJ, Schiltz RL, et al. (1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.". Cell 90 (3): 569–80. PMID 9267036. 
  • Spencer TE, Jenster G, Burcin MM, et al. (1997). "Steroid receptor coactivator-1 is a histone acetyltransferase.". Nature 389 (6647): 194–8. doi:10.1038/38304. PMID 9296499. 
  • Takeshita A, Cardona GR, Koibuchi N, et al. (1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.". J. Biol. Chem. 272 (44): 27629–34. PMID 9346901. 
  • Korzus E, Torchia J, Rose DW, et al. (1998). "Transcription factor-specific requirements for coactivators and their acetyltransferase functions.". Science 279 (5351): 703–7. PMID 9445475. 
  • Puri PL, Sartorelli V, Yang XJ, et al. (1998). "Differential roles of p300 and PCAF acetyltransferases in muscle differentiation.". Mol. Cell 1 (1): 35–45. PMID 9659901. 
  • Ogryzko VV, Kotani T, Zhang X, et al. (1998). "Histone-like TAFs within the PCAF histone acetylase complex.". Cell 94 (1): 35–44. PMID 9674425. 
  • Randhawa GS, Bell DW, Testa JR, Feinberg AP (1998). "Identification and mapping of human histone acetylation modifier gene homologues.". Genomics 51 (2): 262–9. doi:10.1006/geno.1998.5370. PMID 9722949. 
  • Benkirane M, Chun RF, Xiao H, et al. (1998). "Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat.". J. Biol. Chem. 273 (38): 24898–905. PMID 9733796. 

[edit] External links

 This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription coregulators
Coactivators
ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1
NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)
Corepressors
Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33)
NCOR1 - NCOR2 (SMRT)
ATP-dependent remodeling factors