PBRM1

From Wikipedia, the free encyclopedia

Polybromo 1

PDB rendering based on 1w4s.

Available structures: 1w4s

Identifiers

Symbol(s)

PB1; BAF180; MGC156155; MGC156156

External IDs

OMIM: 606083 MGI: 1923998 HomoloGene: 10044

Gene ontology
Molecular Function:	• DNA binding • chromatin binding • protein binding
Cellular Component:	• nuclear chromosome • nucleus
Biological Process:	• chromatin remodeling • transcription • regulation of transcription, DNA-dependent • mitosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_018165 (mRNA)
NP_060635 (protein)

XM_619217 (mRNA)
XP_619217 (protein)

Location

Chr 3: 52.56 - 52.69 Mb

Chr 14: 29.85 - 29.91 Mb

Pubmed search

[1]

[2]

Polybromo 1, also known as PB1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PB1 polybromo 1.

[edit] Further reading

Martens JA, Winston F (2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes.". Curr. Opin. Genet. Dev. 13 (2): 136–42. PMID 12672490.
Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. doi:10.1073/pnas.240208597. PMID 11078522.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMID 11483580.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Lemon B, Inouye C, King DS, Tjian R (2002). "Selectivity of chromatin-remodelling cofactors for ligand-activated transcription.". Nature 414 (6866): 924–8. doi:10.1038/414924a. PMID 11780067.
Olave I, Wang W, Xue Y, et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex.". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMID 12368262.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Horikawa I, Barrett JC (2003). "cDNA cloning of the human polybromo-1 gene on chromosome 3p21.". DNA Seq. 13 (4): 211–5. PMID 12487023.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sekine I, Sato M, Sunaga N, et al. (2005). "The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer.". Oncogene 24 (16): 2735–8. doi:10.1038/sj.onc.1207694. PMID 15735765.
Yan Z, Cui K, Murray DM, et al. (2005). "PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.". Genes Dev. 19 (14): 1662–7. doi:10.1101/gad.1323805. PMID 15985610.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chandrasekaran R, Thompson M (2007). "Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions.". Biochem. Biophys. Res. Commun. 355 (3): 661–6. doi:10.1016/j.bbrc.2007.01.193. PMID 17320048.