PBK (gene)

From Wikipedia, the free encyclopedia

PDZ binding kinase

Identifiers

PBK; SPK; FLJ14385; Nori-3; TOPK

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• protein amino acid phosphorylation • mitosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018492 (mRNA)
NP_060962 (protein)

XM_994462 (mRNA)
XP_999556 (protein)

Location

Chr 8: 27.72 - 27.75 Mb

Chr 14: 64.76 - 64.77 Mb

Pubmed search

[1]

[2]

PDZ binding kinase, also known as PBK, is a human gene.^[1]

The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: PBK PDZ binding kinase.

[edit] Further reading

Gaudet S, Branton D, Lue RA (2000). "Characterization of PDZ-binding kinase, a mitotic kinase.". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5167–72. doi:10.1073/pnas.090102397. PMID 10779557.
Abe Y, Matsumoto S, Kito K, Ueda N (2000). "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells.". J. Biol. Chem. 275 (28): 21525–31. doi:10.1074/jbc.M909629199. PMID 10781613.
Zhao S, Dai J, Zhao W, et al. (2001). "PDZ-binding kinase participates in spermatogenesis.". Int. J. Biochem. Cell Biol. 33 (6): 631–6. PMID 11378444.
Simons-Evelyn M, Bailey-Dell K, Toretsky JA, et al. (2003). "PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells.". Blood Cells Mol. Dis. 27 (5): 825–9. doi:10.1006/bcmd.2001.0452. PMID 11783945.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.". Genomics 81 (2): 112–25. PMID 12620389.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nandi A, Tidwell M, Karp J, Rapoport AP (2004). "Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells.". Blood Cells Mol. Dis. 32 (1): 240–5. PMID 14757441.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Matsumoto S, Abe Y, Fujibuchi T, et al. (2005). "Characterization of a MAPKK-like protein kinase TOPK.". Biochem. Biophys. Res. Commun. 325 (3): 997–1004. doi:10.1016/j.bbrc.2004.10.133. PMID 15541388.
Sabio G, Arthur JS, Kuma Y, et al. (2005). "p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.". EMBO J. 24 (6): 1134–45. doi:10.1038/sj.emboj.7600578. PMID 15729360.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment.". Nat. Methods 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Dougherty JD, Garcia AD, Nakano I, et al. (2006). "PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase.". J. Neurosci. 25 (46): 10773–85. doi:10.1523/JNEUROSCI.3207-05.2005. PMID 16291951.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Nandi AK, Ford T, Fleksher D, et al. (2007). "Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53.". Biochem. Biophys. Res. Commun. 358 (1): 181–8. doi:10.1016/j.bbrc.2007.04.125. PMID 17482142.
Oh SM, Zhu F, Cho YY, et al. (2007). "T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation.". Cancer Res. 67 (11): 5186–94. doi:10.1158/0008-5472.CAN-06-4506. PMID 17545598.
Zhu F, Zykova TA, Kang BS, et al. (2007). "Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.". Gastroenterology 133 (1): 219–31. doi:10.1053/j.gastro.2007.04.048. PMID 17631144.