PBEF1

From Wikipedia, the free encyclopedia

Pre-B-cell colony enhancing factor 1

PDB rendering based on 2g95.

Available structures: 2g95, 2g96, 2g97, 2gvg, 2gvj, 2gvl, 2h3b, 2h3d

Identifiers

Symbol(s)

PBEF1; 1110035O14Rik; DKFZP666B131; MGC117256; NAMPT; PBEF

External IDs

OMIM: 608764 MGI: 1929865 HomoloGene: 4201

Gene ontology
Molecular Function:	• nicotinate phosphoribosyltransferase activity • cytokine activity • transferase activity, transferring glycosyl groups • nicotinamide phosphoribosyltransferase activity
Biological Process:	• signal transduction • cell-cell signaling • positive regulation of cell proliferation • pyridine nucleotide biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005746 (mRNA)
NP_005737 (protein)

NM_021524 (mRNA)
NP_067499 (protein)

Location

Chr 7: 105.68 - 105.71 Mb

Chr 12: 33.41 - 33.44 Mb

Pubmed search

[1]

[2]

Pre-B-cell colony enhancing factor 1, also known as PBEF1, is a human gene.

This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity. This gene has a pseudogene on chromosome 10.^[1]

[edit] References

^ Entrez Gene: PBEF1 pre-B-cell colony enhancing factor 1.

[edit] Further reading

Stephens JM, Vidal-Puig AJ (2007). "An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity.". Curr. Opin. Lipidol. 17 (2): 128–31. doi:10.1097/01.mol.0000217893.77746.4b. PMID 16531748.
Bełtowski J (2006). "Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity?". Med. Sci. Monit. 12 (6): RA112–9. PMID 16733497.
Pilz S, Mangge H, Obermayer-Pietsch B, März W (2007). "Visfatin/pre-B-cell colony-enhancing factor: a protein with various suggested functions.". J. Endocrinol. Invest. 30 (2): 138–44. PMID 17392604.
Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR (1991). "A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes.". DNA Cell Biol. 9 (8): 579–87. PMID 1702972.
Samal B, Sun Y, Stearns G, et al. (1994). "Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor.". Mol. Cell. Biol. 14 (2): 1431–7. PMID 8289818.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Rongvaux A, Shea RJ, Mulks MH, et al. (2003). "Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis.". Eur. J. Immunol. 32 (11): 3225–34. doi:10.1002/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L. PMID 12555668.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Kitani T, Okuno S, Fujisawa H (2003). "Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor.". FEBS Lett. 544 (1-3): 74–8. PMID 12782293.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.". Exp. Cell Res. 289 (2): 211–21. PMID 14499622.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Jia SH, Li Y, Parodo J, et al. (2004). "Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis.". J. Clin. Invest. 113 (9): 1318–27. doi:10.1172/JCI200419930. PMID 15124023.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Fukuhara A, Matsuda M, Nishizawa M, et al. (2005). "Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.". Science 307 (5708): 426–30. doi:10.1126/science.1097243. PMID 15604363.
Janssen JJ, Klaver SM, Waisfisz Q, et al. (2005). "Identification of genes potentially involved in disease transformation of CML.". Leukemia 19 (6): 998–1004. doi:10.1038/sj.leu.2403735. PMID 15815727.
van der Veer E, Nong Z, O'Neil C, et al. (2005). "Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation.". Circ. Res. 97 (1): 25–34. doi:10.1161/01.RES.0000173298.38808.27. PMID 15947248.
Ognjanovic S, Ku TL, Bryant-Greenwood GD (2005). "Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium.". Am. J. Obstet. Gynecol. 193 (1): 273–82. doi:10.1016/j.ajog.2004.11.003. PMID 16021090.