PAXIP1

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PAX interacting (with transcription-activation domain) protein 1
Identifiers
Symbol(s) PAXIP1; CAGF28; CAGF29; FLJ41049; PACIP1; PAXIP1L; PTIP; TNRC2
External IDs OMIM: 608254 MGI: 1890430 HomoloGene: 68995
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 22976 55982
Ensembl ENSG00000157212 ENSMUSG00000002221
Refseq NM_007349 (mRNA)
NP_031375 (protein)		 NM_018878 (mRNA)
NP_061366 (protein)
Location Chr 7: 154.37 - 154.43 Mb Chr 5: 28.07 - 28.12 Mb
Pubmed search [1] [2]

PAX interacting (with transcription-activation domain) protein 1, also known as PAXIP1, is a human gene.[1]

This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.[1]

[edit] References

  1. ^ a b Entrez Gene: PAXIP1 PAX interacting (with transcription-activation domain) protein 1.

[edit] Further reading

  • Margolis RL, Abraham MR, Gatchell SB, et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain.". Hum. Genet. 100 (1): 114–22. PMID 9225980. 
  • "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074. 
  • Lechner MS, Levitan I, Dressler GR (2000). "PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin.". Nucleic Acids Res. 28 (14): 2741–51. PMID 10908331. 
  • Hoffmeister A, Ropolo A, Vasseur S, et al. (2002). "The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.". J. Biol. Chem. 277 (25): 22314–9. doi:10.1074/jbc.M201657200. PMID 11940591. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cho EA, Prindle MJ, Dressler GR (2003). "BRCT domain-containing protein PTIP is essential for progression through mitosis.". Mol. Cell. Biol. 23 (5): 1666–73. PMID 12588986. 
  • Manke IA, Lowery DM, Nguyen A, Yaffe MB (2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting.". Science 302 (5645): 636–9. doi:10.1126/science.1088877. PMID 14576432. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Jowsey PA, Doherty AJ, Rouse J (2005). "Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation.". J. Biol. Chem. 279 (53): 55562–9. doi:10.1074/jbc.M411021200. PMID 15456759. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Cho YW, Hong T, Hong S, et al. (2007). "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.". J. Biol. Chem. 282 (28): 20395–406. doi:10.1074/jbc.M701574200. PMID 17500065. 
  • Munoz IM, Jowsey PA, Toth R, Rouse J (2007). "Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage.". Nucleic Acids Res. 35 (16): 5312–22. doi:10.1093/nar/gkm493. PMID 17690115. 
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