User:Paul Markel

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CURRICULUM VITAE

DATE PREPARED: July, 2006

NAME: Paul D. Markel

OFFICE ADDRESS: Department of Psychology, Minot State University 500 University Ave West, Minot, ND 58707

PHONE: 701 858 4296 (OFFICE)

FAX: 701 839 6933

E-MAIL: tachytron@earthlink.net

EDUCATION:

1990 B.A. University of Mary, Bismarck, ND (Majors: Math/Natural Sciences, Social/Behavioral Sciences; Minors: Chemistry, Biology, Sociology) 1993 M.A. University of Colorado, Boulder, CO (Psychology) 1995 Ph.D. University of Colorado, Boulder, CO (Psychology)

POSTDOCTORAL TRAINING:

1995-1996 Faculty Research Associate Pharmacology

Department of Pharmacology and the School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO

LICENSURE AND CERTIFICATION:

1995 Behavior Genetics Certificate, Institute for Behavioral Genetics, Boulder, CO

ACADEMIC APPOINTMENTS:

1995 Faculty Research Associate, School of Pharmacy, University of Colorado Health Science Center, Denver, CO

1996-1998 Associate Professor of Biomedical Engineering (adjunct), Center for Advanced Biotechnology, Boston University

1996-2001 Assistant Professor of Psychology Minot State University, ND

1998-2000 Lecturer in Medicine, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA

1999-2001 Visiting Professor Center for Statistics Limburgs Universitair Centrum Province of Limburg, Belgium

2001-2007 Associate Professor of Psychology Minot State University, ND

2007- Full Professor of Psychology Minot State University, ND

OTHER PROFESSIONAL POSITIONS AND MAJOR VISITING APPOINTMENTS:

1989-1990 Research Assistant, United States Department of Agriculture 1991-1994 Project Manager, Institute for Behavioral Genetics, Boulder, CO 1995-1996 Statistical Geneticist, Millennium Pharm. Inc., Cambridge, MA 1995-1998 Study Leader, NIMH-Millennium Consortium on the Genetics of Schizophrenia, Cambridge, MA 1996-1999 Statistical Geneticist (consultant), Millennium Pharm. Inc., Cambridge, MA 1998-1999 Principal Consultant, GenoPlex Inc, Denver, CO 1998-2000 Director, Alcohol Genomics Consortium, Denver, CO

MAJOR ADMINISTRATIVE RESPONSIBILITIES

1995-1998 Study Leader NIMH-Millennium Consortium on the Genetics of Schizophrenia Cambridge, MA

1998-2000 Director Alcohol Genomics Consortium, Denver, CO

2003-2005 Director Bush Grant Projects, Minot State University

2001-2002 Vice President, Faculty Senate, Minot State University

2002-2004 President, Faculty Senate, Minot State University

MAJOR COMMITTEE ASSIGNMENTS:

National

1996 Grant Review Group Member Section on Psychology, Behavior, and Neuroscience National Institute of Health

Regional

1997-1998 Curriculum Review Committee Member Minot State University

1997-2003 Bush Foundation Advisory Committee Advisor/Member Minot State University

1997-2001 Board of Directors Board Director Medical Arts Education and Research Charitable Foundation, Medical Arts Clinic, Minot, ND

2000-2001 Bachelor of Arts Evaluation Committee Member Appointed by Dean Dale Elhardt Minot State University

2000- Board of Directors Board Director Psychology Research Institute of North Dakota Minot, ND

2003-2004 Ad hoc Committee on Sabbaticals: Chairman Guidelines, Policy, and Feasibility, Faculty Senate, Minot State University

PROFESSIONAL SOCIETIES:

1990-2001 Behavior Genetics Association Member 1995-1998 International Soc. for Psychiatric Genetics Member 1995-1999 Research Society for Alcoholism Member 1996-2001 American Psychological Association Member 1998-2000 Consulting Psychology, Div. 13, APA Member 1998- Sigma Xi National Science Society Treasurer 1999- New York Academy of Science Member 2001- American Psychological Society Member 2001- Mathematics Association of America Member

EDITORIAL BOARDS:

1995 ad hoc reviewer ComBios 1996 ad hoc reviewer Genetic Epidemiology 1996 ad hoc reviewer New England Journal of Medicine 1997 ad hoc reviewer Neuropsychiatric Genetics 2001 ad hoc reviewer Journal of the Royal Statistical Society

AFFILIATIONS:

2007 Master Mason, Star of the West Lodge #33 Freemasonry AF & AM, Minot, ND (Est. 1889)

AWARDS AND HONORS:

1988 Scholastic All-American Collegiate Award 1988 Who’s Who Among American Colleges 1990 Outstanding Journalism Writing Award University of Mary, Bismarck, ND 1990-1993 Training Grant Fellowship National Institute of Mental Health 1992-1994 Doctoral Fellowship The Graduate School, University of Colorado, Boulder 1993-1994 Training Grant Fellowship National Institute of Child Health and Human Development 1995 NARSAD Young Investigator Fellowship (National Alliance for Research on Schizophrenia and Affective Disorders), Chicago 1998 Research Appointment Vice President for Academic Affairs, Minot State University 1998 Outstanding Young American Award 2000 Who's Who among American Teachers 2001-2005 Who's Who in America, 55th and subsequent Editions 2001 Certificate of Appreciation for Continuous Exemplary Student Evaluations of Instructor and Course, Vice President of Academic Affairs Office, Minot State University 2002 Board of Regents Faculty Achievement Award (Teacher of the Year), Minot State University 2006 Biography under review for Who’s Who (WW) in Medicine and Healthcare, WW in Science and Engineering, and WW in the World

MAJOR RESEARCH INTERESTS: 1. Statistical genetics: methodology and complex traits 2. Behavior genetics 3. Experimental psychology

Overview I am a full-time associate professor, specializing in statistical and experimental methodology. I teach and conduct research in statistical genetics of complex traits, behavior genetics, and experimental psychology. I am primarily concerned with issues of measurement theory (biometrics, psychometrics) and research design as applied to complex biological and psychological systems (e.g., disease, behavior, psychological and social phenomena).

Statistical Genetics I have developed several statistical genetic approaches that advance our ability to study complex traits. I am first author on papers describing novel methodologies for multivariate linkage analysis, genetic segregation analyses of repeated measures, heritability estimates based on molecular data, and theoretical and empirical principles of the rapid development of congenic strains.

I was awarded a Young Investigator fellowship from the National Alliance for Research on Schizophrenia and Affective Disorders, Chicago. I turned this down and instead accepted a position as the first statistical geneticist at Millennium Pharmaceutical (MPI, Cambridge MA) where I was responsible for establishing a statistical genetics team and the analysis of all genetic data for both human and mouse genetic programs. I have served as statistical geneticist on national and international studies of complex disease: asthma (Harvard-Millennium), atherosclerosis, obesity (Milwaukee Medical Center), diabetes (MIT, Joslin Diabetes Center, University of Malmo, Sweden), and schizophrenia (Harvard, Columbia, Washington University).

I am presently developing a genetic epidemiological study of chronic obstructive pulmonary disease in the northern Great Plains in collaboration with Drs. Scott Weiss and Edwin Silverman of the Channing Laboratory. In addition, I am also collaborating with Drs. Kristel van Steen and Gaert Molenbergh, Limburgs Universitair Centrum, Belgium, on the effect of missing data on complex trait analysis.

Behavior Genetics I am trained as behavior geneticist, with an emphasis on molecular and statistical methodology. I was first to publish a genome-wide linkage study of alcohol sensitivity in any mammalian system. In addition, I have published linkages of genes that contribute to differences in neurotensin pharmacology measures.

Recently, I served as Study Leader in the NIMH-Millennium Consortium on the Genetics of Schizophrenia, collaborating with PIs at Columbia, Harvard, and Washington Universities. Our work contributed to a significant scientific and financial alliance between Millennium Pharmaceuticals and Wyeth-Ayrst Pharmaceuticals (Philadelphia) in the area of central nervous system disease, as well as three papers reporting the results of genome wide scans for schizophrenia genes.

Experimental psychology As an experimental psychologist, I conduct research at my university on the cognitive psychology of haptic memory. Also, I am conducting seminal research on a biologically-based model of pleasure attainment and subjective well-being.

RESEARCH FUNDING INFORMATION:

(Note: My research in genetics has been supported primarily by pharmaceutical-industry alliances, e.g., Eli-Lilly etc. I currently secure grant money to cover the expenses of my experimental psychology research from my local university)

1995 National Alliance for Research on Schizophrenia and Affective Disorders

Young Investigator Fellowship PI “A multivariate genetic analysis of affective disorder”

1997-1998 Institutional Small Grant Award, Minot State U., PI

“The structure of attitude with regard to education, materialism, and organized religion”

1997- 1999 Institutional Small Grant Award, Minot State U., PI

“Group cohesion and personality”

REPORT OF TEACHING

LOCAL TEACHING CONTRIBUTIONS:

(Minot State University)

1996- Statistics for the Behavioral Sciences (Psy 241) Assistant Professor 50 students (class), 2 classes/year 12 semester hours/year

1996- Experimental Methodology (Psy 242) Assistant Professor 20 to 45 students (class), 3 class/year 3 semester hours/year

1996- Cognitive Psychology (Psy 410) Assistant Professor 30 to 45 students (class), 1 class/year

3 semester hours/year

1997 Learning Theories (Psy 435) Assistant Professor 20 to 45 students (class), 1 class/year 3 semester hours/year

1997- Physiological Psychology (Psy 465) Assistant Professor 25 students (class), 1 class/year 3 semester hours/year

1997- Psychometric Test Theory and Research Design (Psy 512) Assistant Professor 8 graduate students (class), 1 class/year 3 semester graduate hours/year

1998- Personality Theories (Psy 411) Assistant Professor 45 students (class), 1 class/year 3 semester graduate hours/year

Advising Responsibilities

1996- Post-doctoral Fellow Co-advisor 1 post-doctoral fellow in statistical genetic group/1 summer

1996- Graduate Committee Member 1 Master’s students/year

1997- Undergraduate Advisor Approximately 30 students

1997- Research Assistants, Undergraduates Approximately 4 students/year

1997- Graduate School Advisor Approximately 12 students/year

1998-2004 Psychology Club Advisor Approximately 12 students/year

INTERNATIONAL TEACHING CONTRIBUTIONS:

2000 Statistical Genetics Center for Statistics Limburg Universitair Centrum Diepenbeek, Belgium 30 students (class), 1 class/year

2001 Statistical Genetics Center for Statistics Limburg Universitair Centrum Diepenbeek, Belgium 30 students (class), 1 class/year

REGIONAL, NATIONAL, AND INTERNATIONAL CONTRIBUTIONS:

Invited Presentations

1990 Speaker, Change: The phenomenon of conscious reality, Five State Theological Symposium, St. Mary’s College, Winona, MN.

1991 Poster, QTL mapping of genes conferring ethanol sensitivity, Research Soc. on Alcoholism Scientific Conference, Marcos Island, FL.

1992 Speaker, Detection of QTLs regulating ethanol sensitivity using STS mapping, Research Society on Alcoholism Scientific Conference, LaJolla, CA.

Speaker, Repeatability of ethanol-induced sleep time in mice, Behavior Genetics Association 22nd Annual Meeting, Genetics and Alcohol Symposium, Boulder, CO.

1993 Poster, Detection of QTLs regulating ethanol sensitivity using STS mapping, Fourth Annual Gordon Conference on Quantitative Genetics and Biotechnology, Ventura, CA.

Speaker, Mapping of QTLs regulating ethanol induced anesthesia, World Congress on Psychiatric Genetics, New Orleans, LA.

1994 Poster, Linkage of the albinism gene (Tyr) to a QTL influencing ethanol-induced anesthesia in laboratory mouse: a multivariate analysis of repeated measures, Behavior Genetics Association 24th Annual Meeting, Barcelona, Spain.

Lecture, A Biometrical and molecular-genetic analysis of ethanol-induced anesthesia, hosted by Dr. Martin S. Schalling, Director of Neurogenetics Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

1995 Lecture, A genetic analysis of sleep time in the long-sleep and short-sleep mice, hosted by Dr. Thomas E. Johnson, Professor Institute for Behavioral Genetics, Boulder, CO.

Lecture, Multivariate applications for the linkage analysis of complex traits in human, hosted by Dr. Geoffrey Duyk, Director of Genomics Millennium Pharmaceuticals, Inc, Cambridge, MA.

Lecture, Biometrics and molecular genetics of individual differences in ethanol sensitivity, hosted by Dr. Kenneth S. Kendler, Director of Psychiatric Genetics Department of Psychiatry, Medical College of Virginia, Richmond VA.

1996 Lecture, A molecular and biometrical analysis of alcohol sensitivity, hosted by Drs. Nan Laird and Nik Schork Harvard School of Public Health, Boston, MA.

1997 Speaker, QTL mapping: Progress in mapping alcohol-related traits, hosted by Dr. John Crabbe, Department of Veterans Affairs Medical Center, Portland OR, United States Veteran’s Administration Hallmark Resort, Cannon Beach, Oregon.

1998 Speaker, A genetic analysis of schizophrenia, hosted by the Honorable Janet Wentz, Wade County Chapter National Alliance for the Mentally Ill

Lecture, Using complex systems in the analysis of other complex systems: The NIMH-Millennium Consortium on Schizophrenia, hosted by Ken Collins, Chief Executive Officer GenoPlex Inc., Denver, CO.

Oral presentation, Personality and cohesion among college basketball players, M. Huson and PD Markel, Red River Psychology Conference, Concordia College, Moorhead, MN

Poster, An analysis of attitude structure regarding education, materialism, and religion, JL Reichenberg and PD Markel, Red River Psychology Conference, Concordia College, Moorhead, MN

1999 Lecture, A tool for multiple phenotype analysis with implications for QTL mapping, hosted by Dr. Scott Weiss MD, Channing Laboratory, Harvard University Medical School, Boston, MA

Poster, Sexual activity and happiness, SD Haseleu and PD Markel, Red River Psychology Conference, Moorhead State University, Minnesota

Poster, Exercise and happiness, M Ballenas and PD Markel, Red River Psychology Conference, Moorhead State University, Minnesota

2000 Speaker, A consideration of progress in the genetic analysis of complex traits using a simple model: P = G + E, hosted by Dr. Marc Aerts Royal Statistical Society's Three-Country Meeting (Belgium, Germany, and Holland) Limburg Universitair Centrum, Diepenbeek, Belgium

Speaker, Ethics of genetic research in a clinical environment, Hosted by Karen Haskins, Executive Director of Education North Dakota Healthcare Association 66th Annual Convention Fargo, North Dakota

Poster, Relationship between haptic and visual memory, RD Jameson, A Kelley-Cooper, SD Haseleu, and PD Markel, Red River Psychology Conference, North Dakota State University, Fargo

Poster, Optimism and perceptions of child-rearing experiences, MM Jacobson and PD Markel, Red River Psychology Conference, North Dakota State University, Fargo

Poster, Serial position effects and haptic memory, SD Haseleu, RD Jameson, A Kelley-Cooper, and PD Markel, Red River Psychology Conference, North Dakota State University, Fargo

Poster, Finger differences in haptic memory, A Kelly-Cooper, SD Haseleu, RD Jameson, and PD Markel, Red River Psychology Conference, North Dakota State University, Fargo

2001 Main Speaker, Statistical genetics and behaviour: an overview, Royal Statistical Society's Three-Country Meeting (Belgium, Germany, and Holland) hosted by Dr. Luc Bijnens, Director of Biostatistics Global Development Operations and Technology, Janssen Research Foundation Janssen Pharmaceutica, Beerse, Belgium

Lecture, A genetic analysis of alcohol sensitivity, hosted by Dr. Mark Nawrot, Colloquium Series, Department of Psychology, North Dakota State University, Fargo

Poster, Secondary-group formation within a larger group, R Ruzicka and PD Markel, Northern Lights Psychology Conference, University of North Dakota, Grand Forks, North Dakota

2005 Poster, The Phalangeal Communication System, PD Markel and T Linares, 6th Annual Conference of the Augmentative and Alternative Communication Division, American Speech and Hearing Association, Wyndham Resort, Palm Springs, CA, January 28-31

Speaker, Development of a Self-Report Instrument for Pleasure Attainment, PD Markel, Northern Lights Psychology Conference Department of Psychology, University of North Dakota, Grand Forks, ND October 15

BIBLIOGRAPHY:

Original Reports

1. Johnson, TE, DeFries JC, Markel PD (1992). Mapping quantitative trait loci for behavioral traits in the mouse. Behavior Genetics, 22, 635-653.

2. Markel PD and Johnson TE (1994). Initial characterization of STS markers in the LSXSS series of recombinant inbred strains. Mammalian Genome, 5, 199-202.

3. Markel PD and Corley R (1994). A multivariate analysis of repeated measures: Linkage of the albinism locus (Tyr) to a QTL influencing ethanol-induced anesthesia in laboratory mouse. Psychiatric Genetics, 4, 205-210.

4. Bennett B, Markel PD, Beeson MA, Gordon L, and Johnson TE (1994). Mapping quantitative trait loci for ethanol-induced anesthesai in LSXSS recombinant inbred and F2 mice: Methodology and results. Alcohol Alcohol Suppl., 2, 79-86.

5. Markel PD, DeFries JC, Johnson TE (1995). Ethanol-induced anesthesia in inbred strains of long-sleep and short-sleep mice: A genetic analysis using repeated measures and censored data. Behavior Genetics, 25, 67-73.

6. Markel PD, DeFries JC, Johnson TE (1995). Use of repeated measures in an analysis of ethanol-induced loss of righting reflex in inbred long-sleep and short-sleep mice. Alcoholism: Clinical and Experimental Research, 19, 299-304.

7. Markel PD, Fulker DW, Bennett B, Corley RP, DeFries JC, Johnson TE (1996). Quantitative trait loci for ethanol sensitivity in the LSXSS recombinant inbred strains: Interval mapping. Behavior Genetics, 26, 447-457.

8. Markel, PD, Bennett B, Beeson MA, Gordon L, Simpson VJ, Johnson TE (1996). Strain distribution patterns for genetic markers in the LSXSS recombinant-inbred series. Mammalian Genome, 7, 408-412.

9. Christensen, SC, et al. (1996). Quantitative trait locus analyses of sleep-times induced by sedative-hypnotics in LSXSS recombinant inbred strains of mice. Alcoholism: Clinical and Experimental Research, 20, 543-550.

10. Erwin VG, Markel PD, Johnson TJ, Gehle V, and Jones BC (1997). Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects. Journal of Pharmacology and Experimental Therapeutics, 280, 911-918.

11. Markel PD, Bennett B, Beeson MA, Gordon L, and Johnson TE (1997). Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice. Genome Research, 7, 92-99.

12. Glucksman MA, Lehto M, Tayber O, Berkemeier L, Pulido JC, Wu Ye, Nir W-J, Lei F, Markel PD et al. (1997). Novel mutations and a mutational hotspot in the MODY3 gene. Diabetes, 46, 1081-1086.

13. Markel PD, Shu P, Smutko J, Nagle D, Duyk GM, Moore K (1997). Theoretical and empirical issues for marker-assisted breeding of congenic strains. Nature Genetics, 17, 280-284.

14. Kaufman CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD, Meyer J, Zambuto CT, Schmitt K, Maatise TC, Harkavy-Friedman JM, Hampe C, Lee H, Shore D, Wynne D, Moldin SO, Faraone SV, Tsuang MT, Cloninger CR (1998). The NIMH Genetics Initiative Millennium Schizophrenia Consortium: Linkage analysis of African-American pedigrees. American Journal of Medical Genetics, 4, 282-289.

15. Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B, Hampe C, Zambuto CT, Schmitt K, Meyer J, Markel PD, Lee H, Harkavy-Friedman J, Shore D, Moldin SO, Wynne D, Kaufmann C, Cloninger CR, Tsuang MT (1998). Genome scan of the European-American schizophrenia pedigrees: results of the NIMH genetics initiative and Millennium consortium. American Journal of Medical Genetics, 81, 290-295.

16. Cloninger, CR, Kaufman CA, Faraone SV, Malaspina D, Svrakic D, Harkavy-Friedman J, Suarez BK, Matise TC, Shore D, Lee H, Hampe CL, Wynne D, Drain C, Markel PD, Zambuto CT, Schmitt K, Tsuang MT (1998). Genome-wide search for schizophrenia susceptibility loci: The NIMH Genetics Initiative and Millennium Consortium. American Journal of Medical Genetics, 81, 275-281.

17. Hall, PS, Kost, AM, Fretty, KM, and Markel, PD (1998). Treatment of children with oppositional defiant disorder (ODD). The North Dakota Journal of Human Services, 2, 14-21.

18. Markel, PD, and Erwin, VG (1999). Allele dose analysis in recombinant inbred strains: A tool for multiple phenotype analysis with implications for QTL mapping. Alcoholism: Clinical and Experimental Research, 23, 605-610.

19. Van Steen, K, Laird, NM, Markel, P, Molenberghs, G (2007). Approaches to handling incomplete data in family-based association testing. Annals of Human Genetics, 71, 141-151

20. Braekers, R, and Markel, PD (2006). Modeling ethanol-induced sleeping time in inbred strains of mice: A repeated measures design with left-censored data. Statistical Modeling: An International Journal (submitted).

Manuscripts in Development

1. Markel, PD (submitted). Initial characterization of a self-report instrument for pleasure attainment.

2. Markel, PD, Guilbert, SD, and Olson, DJ (in preparation). Characteristics of memory for touch of the hand.

3. Markel, PD, and Linares T (in preparation). The phalangeal communication system: Taptalk.

Dissertation (PhD)

Markel, PD (1995). A molecular-genetic analysis of ethanol-induced anesthesia in the LSXSS recombinant-inbred strains. Boulder, Colorado: University of Colorado, 206 pages.

Major Administrative Reports

1. Markel, PD (2001). Self Study of the Psychology Program, Minot State University. Prepared for the State Board of Higher Education, North Dakota University System. 64 pages.

2. Markel, PD, Harbort, B, Haskins, B, McCormack, D, Royer, R, Seymour, T, and Stokes, K (2004). Ad hoc Committee Report on Sabbaticals: Guidelines, Policy, and Feasibility. 7 pages.

3. Hall, N, Markel, P, and Sanders, M (2004). Report to the Bush Foundation: Collaboration for the Improvement of Undergraduate Teaching and Learning. 52 pages.

4. Markel, PD, Hall, N, and Sanders, M (2005). Final Report to the Bush Foundation: Collaboration for the Improvement of Undergraduate Teaching and Learning. 76 pages.

Books And Other Manuscripts

1. Markel, PD © 1998-2004. Rambling: A collection of essays. (unpublished manuscript) 405 pages.

2. Markel, PD © 2004-2006. Changeling (novel). 402 pages.

3. Markel, PD © 2005. The Crate (novel; under revision). 272 pages.

4. Markel, PD (in preparation). The Confluence (novel).

References

1. Dr. Casey Coleman, Director, School Psychology, Minot State University 701 858 4262

2. Professor Steve Hayton, Dept. of Math and Computer Science, Minot State University 701 858 3075

3. Dr. Tom Linares, Chair, Dept. of Communication Disorders and Special Education, Minot State University 701 858 3057

4. Dr. Stephen Faraone, Associate Professor of Psychology, Department of Psychiatry, Harvard University sfaraone@hms.harvard.edu