Patterson syndrome
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| Patterson syndrome Classification and external resources |
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| OMIM | 169170 |
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Patterson syndrome, also called pseudoleprechaunism, is an extremely rare syndrome, first mistaken as Donohue Syndrome (also known as Leprechaunism).
It is named for Joseph H. Patterson.[1] It was described by Patterson and Watkins in 1962. [2]
The pathogenesis and etiology of the Patterson syndrome was unknown as of 1981.[3]
[edit] Presentation
Patterson syndrome is characterized by the patient's having an unusual facial look, similar to that caused by Leprechaunism. It primarily affects the connective tissue and the neuroendocrine system, giving rise to bronzed hyperpigmentation, cutis laxa of the hands and feet, bodily disproportion, severe mental retardation, and major bony deformities. Radiographs reveal a characteristic generalised skeletal dysplasia.
It comprises endocrine abnormality, hyperadrenocorticism, cushingoid features, and diabetes mellitus. One other case has shown premature adrenarche.
[edit] References
- ^ Dr. Patterson, influential past president of AAP Georgia Chapter -- Samson 27 (7): 39 -- AAP News. Retrieved on 2008-03-24.
- ^ PATTERSON JH, WATKINS WL (1962). "Leprechaunism in a male infant". J. Pediatr. 60: 730–9. PMID 14484402.
- ^ David TJ, Webb BW, Gordon IR (1981). "The Patterson syndrome, leprechaunism, and pseudoleprechaunism". J. Med. Genet. 18 (4): 294–8. PMID 7277424.
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