PARP4

From Wikipedia, the free encyclopedia

Poly (ADP-ribose) polymerase family, member 4

Identifiers

PARP4; ADPRTL1; PARPL; PH5P; VAULT3; VPARP; p193

External IDs

OMIM: 607519 MGI: 2685589 HomoloGene: 4699

Gene ontology
Molecular Function:	• DNA binding • NAD+ ADP-ribosyltransferase activity • transferase activity, transferring glycosyl groups • enzyme binding
Cellular Component:	• intracellular • nucleus • ribonucleoprotein complex
Biological Process:	• DNA repair • protein amino acid ADP-ribosylation • transport • inflammatory response • cell death • response to drug

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006437 (mRNA)
NP_006428 (protein)

XM_978866 (mRNA)
XP_983960 (protein)

Location

Chr 13: 23.89 - 23.98 Mb

n/a

Pubmed search

[1]

[2]

Poly (ADP-ribose) polymerase family, member 4, also known as PARP4, is a human gene.^[1]

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.^[1]

[edit] References

^ ^a ^b Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4.

[edit] Further reading

Jean L, Risler JL, Nagase T, et al. (1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6-8. PMID 10100603.
Soldani C, Scovassi AI (2003). "Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update.". Apoptosis 7 (4): 321-8. PMID 12101391.
Bouchard VJ, Rouleau M, Poirier GG (2003). "PARP-1, a determinant of cell survival in response to DNA damage.". Exp. Hematol. 31 (6): 446-54. PMID 12829019.
Soares MB, Bonaldo MF, Jelene P, et al. (1994). "Construction and characterization of a normalized cDNA library.". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228-32. PMID 7937745.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17-24. PMID 8724849.
Kickhoefer VA, Siva AC, Kedersha NL, et al. (1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.". J. Cell Biol. 146 (5): 917-28. PMID 10477748.
Kickhoefer VA, Stephen AG, Harrington L, et al. (2000). "Vaults and telomerase share a common subunit, TEP1.". J. Biol. Chem. 274 (46): 32712-7. PMID 10551828.
Still IH, Vince P, Cowell JK (2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein.". Genomics 62 (3): 533-6. doi:10.1006/geno.1999.6024. PMID 10644454.
Siva AC, Raval-Fernandes S, Stephen AG, et al. (2001). "Up-regulation of vaults may be necessary but not sufficient for multidrug resistance.". Int. J. Cancer 92 (2): 195-202. PMID 11291045.
van Zon A, Mossink MH, Schoester M, et al. (2001). "Multiple human vault RNAs. Expression and association with the vault complex.". J. Biol. Chem. 276 (40): 37715-21. doi:10.1074/jbc.M106055200. PMID 11479319.
van Zon A, Mossink MH, Schoester M, et al. (2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly.". Biochem. Biophys. Res. Commun. 291 (3): 535-41. doi:10.1006/bbrc.2002.6472. PMID 11855821.
Mazzon E, Dugo L, Li JH, et al. (2002). "GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat.". Biochem. Pharmacol. 64 (2): 327-37. PMID 12123754.
Liu TJ, Lin SY, Chau YP (2002). "Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.". Toxicol. Appl. Pharmacol. 182 (2): 116-25. PMID 12140175.
Nie Z, Phenix BN, Lum JJ, et al. (2003). "HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation.". Cell Death Differ. 9 (11): 1172-84. doi:10.1038/sj.cdd.4401094. PMID 12404116.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Liu Y, Snow BE, Kickhoefer VA, et al. (2004). "Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo.". Mol. Cell. Biol. 24 (12): 5314-23. doi:10.1128/MCB.24.12.5314-5323.2004. PMID 15169895.