PARP10

From Wikipedia, the free encyclopedia

Poly (ADP-ribose) polymerase family, member 10

PDB rendering based on 2dhx.

Available structures: 2dhx

Identifiers

Symbol(s)

PARP10; FLJ14464

External IDs

OMIM: 609564 HomoloGene: 53133

Gene ontology
Molecular Function:	• NAD+ ADP-ribosyltransferase activity • transferase activity, transferring glycosyl groups
Cellular Component:	• insoluble fraction • nucleus • contractile fiber
Biological Process:	• protein amino acid ADP-ribosylation

Orthologs

Human

Mouse

n/a

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Refseq

XM_001127571 (mRNA)
XP_001127571 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 8: 145.12 - 145.13 Mb

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Pubmed search

[1]

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Poly (ADP-ribose) polymerase family, member 10, also known as PARP10, is a human gene.^[1]

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10.

[edit] Further reading

Amé JC, Spenlehauer C, de Murcia G (2004). "The PARP superfamily.". Bioessays 26 (8): 882-93. doi:10.1002/bies.20085. PMID 15273990.
Chou HY, Chou HT, Lee SC (2006). "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10).". J. Biol. Chem. 281 (22): 15201-7. doi:10.1074/jbc.M506745200. PMID 16455663.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Yu M, Schreek S, Cerni C, et al. (2005). "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.". Oncogene 24 (12): 1982-93. doi:10.1038/sj.onc.1208410. PMID 15674325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.