PARD6A

From Wikipedia, the free encyclopedia

Par-6 partitioning defective 6 homolog alpha (C. elegans)

PDB rendering based on 1wmh.

Available structures: 1wmh

Identifiers

Symbol(s)

PARD6A; PAR-6A; PAR6; PAR6C; PAR6alpha; TAX40; TIP-40

External IDs

OMIM: 607484 MGI: 1927223 HomoloGene: 9661

Gene ontology
Molecular Function:	• transcription factor binding • Rho GTPase binding • GTP-dependent protein binding
Cellular Component:	• nucleus • cytoplasm • tight junction • cell cortex • membrane
Biological Process:	• cell cycle • viral reproduction • establishment of cell polarity • intercellular junction maintenance • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001037281 (mRNA)
NP_001032358 (protein)

NM_001047435 (mRNA)
NP_001040900 (protein)

Location

Chr 16: 66.25 - 66.25 Mb

Chr 8: 108.59 - 108.59 Mb

Pubmed search

[1]

[2]

Par-6 partitioning defective 6 homolog alpha (C. elegans), also known as PARD6A, is a human gene.^[1]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans).

[edit] Further reading

Solecki DJ, Govek EE, Hatten ME (2006). "mPar6 alpha controls neuronal migration.". J. Neurosci. 26 (42): 10624–5. doi:10.1523/JNEUROSCI.4060-06.2006. PMID 17050699.
Rousset R, Fabre S, Desbois C, et al. (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.". Oncogene 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.
Qiu RG, Abo A, Steven Martin G (2000). "A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation.". Curr. Biol. 10 (12): 697–707. PMID 10873802.
Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474.
Johansson A, Driessens M, Aspenström P (2000). "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.". J. Cell. Sci. 113 ( Pt 18): 3267–75. PMID 10954424.
Suzuki A, Yamanaka T, Hirose T, et al. (2001). "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.". J. Cell Biol. 152 (6): 1183–96. PMID 11257119.
Noda Y, Takeya R, Ohno S, et al. (2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.". Genes Cells 6 (2): 107–19. PMID 11260256.
Kohjima M, Noda Y, Takeya R, et al. (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.". Biochem. Biophys. Res. Commun. 299 (4): 641–6. PMID 12459187.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hurd TW, Gao L, Roh MH, et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177.
Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Lemmers C, Michel D, Lane-Guermonprez L, et al. (2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells.". Mol. Biol. Cell 15 (3): 1324–33. doi:10.1091/mbc.E03-04-0235. PMID 14718572.
Weyrich P, Kapp K, Niederfellner G, et al. (2005). "Partitioning-defective protein 6 regulates insulin-dependent glycogen synthesis via atypical protein kinase C.". Mol. Endocrinol. 18 (5): 1287–300. doi:10.1210/me.2003-0253. PMID 14976222.
Liu XF, Ishida H, Raziuddin R, Miki T (2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMID 15254234.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hirano Y, Yoshinaga S, Takeya R, et al. (2005). "Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains.". J. Biol. Chem. 280 (10): 9653–61. doi:10.1074/jbc.M409823200. PMID 15590654.
Weyrich P, Lammers R, Fritsche A, et al. (2005). "A novel functional polymorphism (-336A/G) in the promoter of the partitioning-defective protein-6alpha gene is associated with increased glucose tolerance and lower concentrations of serum non-esterified fatty acids.". Diabetologia 48 (4): 669–74. doi:10.1007/s00125-005-1688-4. PMID 15744531.
Ozdamar B, Bose R, Barrios-Rodiles M, et al. (2005). "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.". Science 307 (5715): 1603–9. doi:10.1126/science.1105718. PMID 15761148.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.