PARC (gene)

From Wikipedia, the free encyclopedia

P53-associated parkin-like cytoplasmic protein

Identifiers

PARC; DKFZp686G1042; DKFZp686P2024; H7AP1; RP3-330M21.2

External IDs

OMIM: 607489 MGI: 1925559 HomoloGene: 56696

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • zinc ion binding • metal ion binding
Cellular Component:	• anaphase-promoting complex
Biological Process:	• ubiquitin cycle • cell cycle • regulation of mitotic metaphase/anaphase transition

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015089 (mRNA)
NP_055904 (protein)

XM_001002784 (mRNA)
XP_001002784 (protein)

Location

Chr 6: 43.26 - 43.3 Mb

Chr 17: 45.96 - 46 Mb

Pubmed search

[1]

[2]

P53-associated parkin-like cytoplasmic protein, also known as PARC, is a human gene.^[1]

[edit] References

^ Entrez Gene: PARC p53-associated parkin-like cytoplasmic protein.

[edit] Further reading

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169-76. PMID 9734811.
Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.". J. Biol. Chem. 274 (43): 30963-8. PMID 10521492.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Nikolaev AY, Li M, Puskas N, et al. (2003). "Parc: a cytoplasmic anchor for p53.". Cell 112 (1): 29-40. PMID 12526791.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Issaeva N, Bozko P, Enge M, et al. (2005). "Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.". Nat. Med. 10 (12): 1321-8. doi:10.1038/nm1146. PMID 15558054.
Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.". J. Biol. Chem. 281 (24): 16193-6. doi:10.1074/jbc.C600041200. PMID 16672220.
Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.". J. Biol. Chem. 282 (15): 11300-7. doi:10.1074/jbc.M611297200. PMID 17298945.
Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes.". Cancer Res. 67 (5): 2006-14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.