Pantothenoylcysteine decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a pantothenoylcysteine decarboxylase (EC 4.1.1.30) is an enzyme that catalyzes the chemical reaction

N-[(R)-pantothenoyl]-L-cysteine pantetheine + CO₂

Hence, this enzyme has one substrate, N-((R)-pantothenoyl)-L-cysteine, and two products, pantetheine and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming). Other names in common use include pantothenylcysteine decarboxylase, and N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase. This enzyme participates in pantothenate and coa biosynthesis.

[edit] References

• IUBMB entry for 4.1.1.30
• BRENDA references for 4.1.1.30 (Recommended.)
• PubMed references for 4.1.1.30
• PubMed Central references for 4.1.1.30
• Google Scholar references for 4.1.1.30
• BROWN GM (1957). "Pantothenylcysteine, a precursor of pantetheine in Lactobacillus helveticus". J. Biol. Chem. 226: 651–61. PMID 13438850. 

[edit] External links

The CAS registry number for this enzyme class is 9024-65-1.

• IUBMB entry for 4.1.1.30

• KEGG entry for 4.1.1.30

• BRENDA entry for 4.1.1.30

• NiceZyme view of 4.1.1.30

• EC2PDB: PDB structures for 4.1.1.30

• PRIAM entry for 4.1.1.30

• PUMA2 entry for 4.1.1.30

• IntEnz: Integrated Enzyme entry for 4.1.1.30

• MetaCyc entry for 4.1.1.30

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050167: pantothenoylcysteine decarboxylase

• AMIGO entry for GO code 0050167: pantothenoylcysteine decarboxylase