Pantetheine-phosphate adenylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a pantetheine-phosphate adenylyltransferase (EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction

ATP + pantetheine 4'-phosphate $\rightleftharpoons$ diphosphate + 3'-dephospho-CoA

Thus, the two substrates of this enzyme are ATP and pantetheine 4'-phosphate, whereas its two products are diphosphate and 3'-dephospho-CoA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. This enzyme participates in pantothenate and coa biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1B6T, 1GN8, 1H1T, 1O6B, 1OD6, 1QJC, 1TFU, and 1VLH.

[edit] References

IUBMB entry for 2.7.7.3
BRENDA references for 2.7.7.3 (Recommended.)
PubMed references for 2.7.7.3
PubMed Central references for 2.7.7.3
Google Scholar references for 2.7.7.3
HOAGLAND MB, NOVELLI GD (1954). "Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate". J. Biol. Chem. 207: 767–73. PMID 13163064.
NOVELLI GD (1953). "Enzymatic synthesis and structure of CoA". Fed. Proc. 12: 675–81. PMID 13107738.
Martin DP, Drueckhammer DG (1993). "Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase". Biochem. Biophys. Res. Commun. 192: 1155–61. doi:10.1006/bbrc.1993.1537. PMID 8389542.
Geerlof A, Lewendon A, Shaw WV (1999). "Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli". J. Biol. Chem. 274: 27105–11. doi:10.1074/jbc.274.38.27105. PMID 10480925.
Izard T, Geerlof A, Lewendon A, Barker JJ (Pt 6). "Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli". Acta. Crystallogr. D. Biol. Crystallogr. 55: 1226–8. doi:10.1107/S0907444999004394. PMID 10329792.