Pancreatic polypeptide

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IHC for Pancreatic Polypeptide in a mouse pancreas, 200x.
pancreatic polypeptide
Identifiers
Symbol	PPY
Entrez	5539
HUGO	9327
OMIM	167780
RefSeq	NM_002722
UniProt	P01298
Other data
Locus	Chr. 17 p11.1-qter

Pancreatic polypeptide is a polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas. It consists of 36 amino acids and has molecular weight about 4200 Da.

The function of PP is unknown, but effects on hepatic glycogen levels and gastrointestinal secretions have been suggested. For instance, it is thought to be a cholecystokinin antagonist, and thus suppress the pancreatic secretion and stimulate gastric secretion.

Its secretion in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose.

[edit] External links

• Physiology at MCG 6/6ch2/s6ch2_25
• MeSH Pancreatic+polypeptide
• BBC Hope over 'obesity-busting gum' 15 January 2007

v • d • e Endocrine system > Pancreas – Islets of Langerhans A/B alpha cell (glucagon) • beta cell (insulin) Other delta cell (somatostatin) • PP cell (pancreatic polypeptide) • epsilon cell (ghrelin)

v • d • e Peptides: neuropeptides Hypothalamic Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin) Gastrointestinal hormones Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide Other hormones Vasopressin - Calcitonin - Other Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide