Pancreatic lipase family

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Complex of human pancreatic lipase with colipase
Identifiers
Symbol Lipase
Pfam PF00151
InterPro IPR013818
PROSITE PDOC00110
SCOP 1lpa
OPM protein 1lpa
Available PDB structures:

1rp1 :18-353 1lpaB:17-352 1gpl :24-352 1n8sA:17-352 1lpbB:17-352 1ethC:1-336 1hplB:13-348 1bu8A:17-353


Triglyceride lipases (EC 3.1.1.3) are a family of lipolytic enzymes that hydrolyse ester linkages of triglycerides[1]. Lipases are widely distributed in animals, plants and prokaryotes.

At least three tissue-specific isozymes exist in higher vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (EC 3.1.1.34), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL)[2].

The most conserved region in all these proteins is centred around a serine residue which has been shown[3] to participate, with an histidine and an aspartic acid residue, in a charge relay system. Such a region is also present in lipases of prokaryotic origin and in lecithin-cholesterol acyltransferase (EC 2.3.1.43) (LCAT)[4], which catalyzes fatty acid transfer between phosphatidylcholine and cholesterol.

[edit] Human proteins containing this domain

LIPC; LIPG; LIPH; LIPI; LPL; PLA1A; PNLIP; PNLIPRP1; PNLIPRP2; PNLIPRP3;

[edit] References

  1. ^ Chapus C, Rovery M, Sarda L, Verger R (1988). "Minireview on pancreatic lipase and colipase". Biochimie 70 (9): 1223–1234. doi:10.1016/0300-9084(88)90188-5. PMID 3147715. 
  2. ^ Persson B, Bengtsson-Olivecrona G, Enerback S, Olivecrona T, Jornvall H (1989). "Structural features of lipoprotein lipase. Lipase family relationships, binding interactions, non-equivalence of lipase cofactors, vitellogenin similarities and functional subdivision of lipoprotein lipase". Eur. J. Biochem. 179 (1): 39–45. doi:10.1111/j.1432-1033.1989.tb14518.x. PMID 2917565. 
  3. ^ Blow D (1990). "Enzymology. More of the catalytic triad". Nature 343 (6260): 694–695. doi:10.1038/343694a0. PMID 2304545. 
  4. ^ McLean J, Fielding C, Drayna D, Dieplinger H, Baer B, Kohr W, Henzel W, Lawn R (1986). "Cloning and expression of human lecithin-cholesterol acyltransferase cDNA". Proc. Natl. Acad. Sci. U.S.A. 83 (8): 2335–2339. doi:10.1073/pnas.83.8.2335. PMID 3458198. 

[edit] Further reading

  • [1]. Structure and activity of rat pancreatic lipase-related protein 2. Roussel A, Yang Y, Ferrato F, Verger R, Cambillau C, Lowe M; J Biol Chem 1998;273:32121-32128. PubMed

This article includes text from the public domain Pfam and InterPro IPR013818

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