PANK1

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Pantothenate kinase 1
PDB rendering based on 2i7n.
Available structures: 2i7n
Identifiers
Symbol(s) PANK1; MGC24596; PANK; PANK1a; PANK1b
External IDs OMIM: 606160 MGI: 1922985 HomoloGene: 56979
Orthologs
Human Mouse
Entrez 53354 75735
Ensembl ENSG00000152782 ENSMUSG00000033610
Uniprot Q8TE04 Q543J7
Refseq NM_138316 (mRNA)
NP_612189 (protein)		 XM_973598 (mRNA)
XP_978692 (protein)
Location Chr 10: 91.33 - 91.4 Mb Chr 19: 34.88 - 34.95 Mb
Pubmed search [1] [2]

Pantothenate kinase 1, also known as PANK1, is a human gene.[1]

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: PANK1 pantothenate kinase 1.

[edit] Further reading

  • Robishaw JD, Neely JR (1985). "Coenzyme A metabolism.". Am. J. Physiol. 248 (1 Pt 1): E1-9. PMID 2981478. 
  • Hong BS, Senisterra G, Rabeh WM, et al. (2007). "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.". J. Biol. Chem. 282 (38): 27984-93. doi:10.1074/jbc.M701915200. PMID 17631502. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054. 
  • Ramaswamy G, Karim MA, Murti KG, Jackowski S (2004). "PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.". J. Lipid Res. 45 (1): 17-31. doi:10.1194/jlr.M300279-JLR200. PMID 14523052. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Westaway SK, Hayflick SJ, Zhou B, Gitschier JD (2003). "In reference to the Short Communication published by Ni et al.". Int. J. Biochem. Cell Biol. 34 (12): 1629. PMID 12379284. 
  • Ni X, Ma Y, Cheng H, et al. (2002). "Cloning and characterization of a novel human pantothenate kinase gene.". Int. J. Biochem. Cell Biol. 34 (2): 109-15. PMID 11809413. 
  • Zhou B, Westaway SK, Levinson B, et al. (2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.". Nat. Genet. 28 (4): 345-9. doi:10.1038/ng572. PMID 11479594. 
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