Palmitoyl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a palmitoyl-CoA hydrolase (EC 3.1.2.2) is an enzyme that catalyzes the chemical reaction

palmitoyl-CoA + H₂O CoA + palmitate

Thus, the two substrates of this enzyme are palmitoyl-CoA and H₂O, whereas its two products are CoA and palmitate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is palmitoyl-CoA hydrolase. Other names in common use include long-chain fatty-acyl-CoA hydrolase, palmitoyl coenzyme A hydrolase, palmitoyl thioesterase, palmitoyl coenzyme A hydrolase, palmitoyl-CoA deacylase, palmityl thioesterase, palmityl-CoA deacylase, fatty acyl thioesterase I, and palmityl thioesterase I.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1TBU, 2Q2B, and 2QQ2.

[edit] References

• IUBMB entry for 3.1.2.2
• BRENDA references for 3.1.2.2 (Recommended.)
• PubMed references for 3.1.2.2
• PubMed Central references for 3.1.2.2
• Google Scholar references for 3.1.2.2
• Barnes EM Jr, Wakil SJ (1968). "Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase". J. Biol. Chem. 243: 2955–62. PMID 4871199. 
• Berge RK, Farstad M (1981). "Long-chain fatty acyl-CoA hydrolase from rat liver mitochondria". Methods. Enzymol. 71 Pt C: 234–42. PMID 6116156. 
• Miyazawa S, Furuta S, Hashimoto T (1981). "Induction of a novel long-chain acyl-CoA hydrolase in rat liver by administration of peroxisome proliferators". Eur. J. Biochem. 117: 425–30. PMID 6115749. 
• Srere PA, Seubert W and Lynen F (1959). "Palmityl coenzyme A deacylase". Biochim. Biophys. Acta 33: 313–319. doi:10.1016/0006-3002(59)90118-0. 
• Yabusaki KK and Ballou CE (1981). "Long-chain fatty acyl-CoA thioesterases from Mycobacterium smegmatis". Methods Enzymol. 71: 242–246. 

[edit] External links

The CAS registry number for this enzyme class is 9025-87-0.

• IUBMB entry for 3.1.2.2

• KEGG entry for 3.1.2.2

• BRENDA entry for 3.1.2.2

• NiceZyme view of 3.1.2.2

• EC2PDB: PDB structures for 3.1.2.2

• PRIAM entry for 3.1.2.2

• PUMA2 entry for 3.1.2.2

• IntEnz: Integrated Enzyme entry for 3.1.2.2

• MetaCyc entry for 3.1.2.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016290: palmitoyl-CoA hydrolase

• AMIGO entry for GO code 0016290: palmitoyl-CoA hydrolase