Palmitoyl(protein) hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a palmitoyl[protein] hydrolase (EC 3.1.2.22) is an enzyme that catalyzes the chemical reaction

palmitoyl[protein] + H₂O $\rightleftharpoons$ palmitate + protein

Thus, the two substrates of this enzyme are [[palmitoyl[protein]]] and H₂O, whereas its two products are palmitate and protein.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is palmitoyl[protein] hydrolase. Other names in common use include palmitoyl-protein thioesterase, and palmitoyl-(protein) hydrolase. This enzyme participates in fatty acid elongation in mitochondria.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1EH5, 1EI9, 1EXW, and 1PJA.

[edit] References

IUBMB entry for 3.1.2.22
BRENDA references for 3.1.2.22 (Recommended.)
PubMed references for 3.1.2.22
PubMed Central references for 3.1.2.22
Google Scholar references for 3.1.2.22
Camp LA, Hofmann SL (1995). "Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate". Methods. Enzymol. 250: 336–47. PMID 7651163.
Schriner JE, Yi W, Hofmann SL (1996). "cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis". Genomics. 34: 317–22. doi:10.1006/geno.1996.0292. PMID 8786130.
Verkruyse LA, Hofmann SL (1996). "Lysosomal targeting of palmitoyl-protein thioesterase". J. Biol. Chem. 271: 15831–6. doi:10.1074/jbc.271.26.15831. PMID 8663305.