PALM

From Wikipedia, the free encyclopedia

Paralemmin

Identifiers

PALM; KIAA0270

External IDs

OMIM: 608134 MGI: 1261814 HomoloGene: 1937

Gene ontology
Cellular Component:	• cytoplasm • plasma membrane • integral to plasma membrane • cytoplasmic membrane-bound vesicle
Biological Process:	• cell motility • cytoskeleton organization and biogenesis • regulation of cell shape

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001040134 (mRNA)
NP_001035224 (protein)

NM_023128 (mRNA)
NP_075617 (protein)

Location

Chr 19: 0.66 - 0.7 Mb

Chr 10: 79.2 - 79.22 Mb

Pubmed search

[1]

[2]

Paralemmin, also known as PALM, is a human gene.^[1]

This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: PALM paralemmin.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
Burwinkel B, Miglierini G, Jenne DE, et al. (1998). "Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice.". Genomics 49 (3): 462–6. doi:10.1006/geno.1998.5276. PMID 9615234.
Kutzleb C, Sanders G, Yamamoto R, et al. (1998). "Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation.". J. Cell Biol. 143 (3): 795–813. PMID 9813098.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D (2005). "Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.". Mol. Biol. Cell 15 (5): 2205–17. doi:10.1091/mbc.E03-07-0493. PMID 14978216.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Basile M, Lin R, Kabbani N, et al. (2006). "Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling.". Arch. Biochem. Biophys. 446 (1): 60–8. doi:10.1016/j.abb.2005.10.027. PMID 16386234.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.