PALB2

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Partner and localizer of BRCA2
Identifiers
Symbol(s) PALB2; DKFZp667I166; DKFZp686E1054; FANCN; FLJ21816
External IDs OMIM: 610355 MGI: 3040695 HomoloGene: 11652
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 79728 233826
Ensembl ENSG00000083093 ENSMUSG00000044702
Uniprot Q86YC2 Q3U0P1
Refseq NM_024675 (mRNA)
NP_078951 (protein)		 XM_485999 (mRNA)
XP_485999 (protein)
Location Chr 16: 23.52 - 23.56 Mb Chr 7: 121.9 - 121.92 Mb
Pubmed search [1] [2]

Partner and localizer of BRCA2, also known as PALB2, is a human gene.[1]

This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.[1]

[edit] References

  1. ^ a b Entrez Gene: PALB2 partner and localizer of BRCA2.

[edit] Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Xia B, Sheng Q, Nakanishi K, et al. (2006). "Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.". Mol. Cell 22 (6): 719–29. doi:10.1016/j.molcel.2006.05.022. PMID 16793542. 
  • Rahman N, Seal S, Thompson D, et al. (2007). "PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.". Nat. Genet. 39 (2): 165–7. doi:10.1038/ng1959. PMID 17200668. 
  • Reid S, Schindler D, Hanenberg H, et al. (2007). "Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer.". Nat. Genet. 39 (2): 162–4. doi:10.1038/ng1947. PMID 17200671. 
  • Xia B, Dorsman JC, Ameziane N, et al. (2007). "Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.". Nat. Genet. 39 (2): 159–61. doi:10.1038/ng1942. PMID 17200672. 
  • Erkko H, Xia B, Nikkilä J, et al. (2007). "A recurrent mutation in PALB2 in Finnish cancer families.". Nature 446 (7133): 316–9. doi:10.1038/nature05609. PMID 17287723. 
  • Tischkowitz M, Xia B, Sabbaghian N, et al. (2007). "Analysis of PALB2/FANCN-associated breast cancer families.". Proc. Natl. Acad. Sci. U.S.A. 104 (16): 6788–93. doi:10.1073/pnas.0701724104. PMID 17420451. 
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