PAK6

From Wikipedia, the free encyclopedia

P21(CDKN1A)-activated kinase 6

PDB rendering based on 2c30.

Available structures: 2c30, 2odb

Identifiers

Symbol(s)

PAK6; PAK5

External IDs

OMIM: 608110 MGI: 2679420 HomoloGene: 23200

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_020168 (mRNA)
NP_064553 (protein)

NM_001033254 (mRNA)
NP_001028426 (protein)

Location

Chr 15: 38.32 - 38.36 Mb

Chr 2: 118.36 - 118.39 Mb

Pubmed search

[1]

[2]

P21(CDKN1A)-activated kinase 6, also known as PAK6, is a human gene.^[1]

This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.^[1]

[edit] References

^ ^a ^b Entrez Gene: PAK6 p21(CDKN1A)-activated kinase 6.

[edit] Further reading

Yang F, Li X, Sharma M, et al. (2001). "Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6.". J. Biol. Chem. 276 (18): 15345-53. doi:10.1074/jbc.M010311200. PMID 11278661.
Lee SR, Ramos SM, Ko A, et al. (2002). "AR and ER interaction with a p21-activated kinase (PAK6).". Mol. Endocrinol. 16 (1): 85-99. PMID 11773441.
Pandey A, Dan I, Kristiansen TZ, et al. (2002). "Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain.". Oncogene 21 (24): 3939-48. doi:10.1038/sj.onc.1205478. PMID 12032833.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ching YP, Leong VY, Wong CM, Kung HF (2003). "Identification of an autoinhibitory domain of p21-activated protein kinase 5.". J. Biol. Chem. 278 (36): 33621-4. doi:10.1074/jbc.C300234200. PMID 12860998.
Schrantz N, da Silva Correia J, Fowler B, et al. (2004). "Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.". J. Biol. Chem. 279 (3): 1922-31. doi:10.1074/jbc.M311145200. PMID 14573606.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kaur R, Liu X, Gjoerup O, et al. (2005). "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.". J. Biol. Chem. 280 (5): 3323-30. doi:10.1074/jbc.M406701200. PMID 15550393.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.