PAK1

From Wikipedia, the free encyclopedia

P21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)

PDB rendering based on 1e0a.

Available structures: 1e0a, 1ees, 1f3m, 1yhv, 1yhw, 2hy8

Identifiers

Symbol(s)

PAK1; MGC130000; MGC130001; PAKalpha

External IDs

OMIM: 602590 MGI: 1339975 HomoloGene: 1936

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• cytoplasm • plasma membrane
Biological Process:	• protein amino acid phosphorylation • apoptosis • ER-nuclear signaling pathway • cytoskeleton organization and biogenesis • JNK cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002576 (mRNA)
NP_002567 (protein)

NM_011035 (mRNA)
NP_035165 (protein)

Location

Chr 11: 76.71 - 76.86 Mb

Chr 7: 97.72 - 97.79 Mb

Pubmed search

[1]

[2]

P21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast), also known as PAK1, is a human gene.

PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternative transcripts of this gene have been found, but their full-length natures have not yet been determined.^[1]

[edit] References

^ Entrez Gene: PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast).

[edit] Further reading

Trono D, Wang JK (1997). "Nef and PAK: virulence factor and cellular accomplice.". Chem. Biol. 4 (1): 13–5. PMID 9070423.
Bagrodia S, Cerione RA (1999). "Pak to the future.". Trends Cell Biol. 9 (9): 350–5. PMID 10461188.
Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741.
Jaffer ZM, Chernoff J (2002). "p21-activated kinases: three more join the Pak.". Int. J. Biochem. Cell Biol. 34 (7): 713–7. PMID 11950587.
Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323–35. PMID 12734410.
Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726.
Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell.". Current HIV/AIDS reports 1 (1): 47–53. PMID 16091223.
Sheehan KA, Ke Y, Solaro RJ (2007). "p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.". Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (3): R963–73. doi:10.1152/ajpregu.00253.2007. PMID 17609315.
Martin GA, Bollag G, McCormick F, Abo A (1995). "A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.". EMBO J. 14 (9): 1970–8. PMID 7744004.
Sawai ET, Baur AS, Peterlin BM, et al. (1995). "A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity.". J. Biol. Chem. 270 (25): 15307–14. PMID 7797518.
Manser E, Leung T, Salihuddin H, et al. (1994). "A brain serine/threonine protein kinase activated by Cdc42 and Rac1.". Nature 367 (6458): 40–6. doi:10.1038/367040a0. PMID 8107774.
Sawai ET, Baur A, Struble H, et al. (1994). "Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 91 (4): 1539–43. PMID 8108442.
Nunn MF, Marsh JW (1996). "Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.". J. Virol. 70 (9): 6157–61. PMID 8709241.
Luo T, Garcia JV (1996). "The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent.". J. Virol. 70 (9): 6493–6. PMID 8709288.
Brown JL, Stowers L, Baer M, et al. (1997). "Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.". Curr. Biol. 6 (5): 598–605. PMID 8805275.
Bokoch GM, Wang Y, Bohl BP, et al. (1996). "Interaction of the Nck adapter protein with p21-activated kinase (PAK1).". J. Biol. Chem. 271 (42): 25746–9. PMID 8824201.
Wiskerchen M, Cheng-Mayer C (1996). "HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis.". Virology 224 (1): 292–301. doi:10.1006/viro.1996.0531. PMID 8862424.
Sawai ET, Khan IH, Montbriand PM, et al. (1997). "Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques.". Curr. Biol. 6 (11): 1519–27. PMID 8939608.
Manser E, Huang HY, Loo TH, et al. (1997). "Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.". Mol. Cell. Biol. 17 (3): 1129–43. PMID 9032240.