PAIP1

From Wikipedia, the free encyclopedia

Poly(A) binding protein interacting protein 1

Identifiers

PAIP1; MGC12360

External IDs

OMIM: 605184 MGI: 2384993 HomoloGene: 4709

Gene ontology
Molecular Function:	• RNA binding • protein binding • translation activator activity
Cellular Component:	• cytoplasm
Biological Process:	• translational initiation • regulation of translation • mRNA stabilization

Orthologs

Human

Mouse

Entrez

10605

218693

Refseq

XM_001128114 (mRNA)
XP_001128114 (protein)

XM_978442 (mRNA)
XP_983536 (protein)

Pubmed search

[1]

[2]

Poly(A) binding protein interacting protein 1, also known as PAIP1, is a human gene.^[1]

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: PAIP1 poly(A) binding protein interacting protein 1.

[edit] Further reading

Craig AW, Haghighat A, Yu AT, Sonenberg N (1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.". Nature 392 (6675): 520-3. doi:10.1038/33198. PMID 9548260.
Gray NK, Coller JM, Dickson KS, Wickens M (2000). "Multiple portions of poly(A)-binding protein stimulate translation in vivo.". EMBO J. 19 (17): 4723-33. doi:10.1093/emboj/19.17.4723. PMID 10970864.
Grosset C, Chen CY, Xu N, et al. (2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.". Cell 103 (1): 29-40. PMID 11051545.
Khaleghpour K, Svitkin YV, Craig AW, et al. (2001). "Translational repression by a novel partner of human poly(A) binding protein, Paip2.". Mol. Cell 7 (1): 205-16. PMID 11172725.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Deo RC, Sonenberg N, Burley SK (2001). "X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein.". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4414-9. doi:10.1073/pnas.071552198. PMID 11287654.
Roy G, De Crescenzo G, Khaleghpour K, et al. (2002). "Paip1 interacts with poly(A) binding protein through two independent binding motifs.". Mol. Cell. Biol. 22 (11): 3769-82. PMID 11997512.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-specific gene duplication and loss in human and great ape evolution.". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMID 15252450.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.