PAFAH1B3

From Wikipedia, the free encyclopedia

Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa

PDB rendering based on 1bwp.

Available structures: 1bwp, 1bwq, 1bwr, 1es9, 1fxw, 1wab

Identifiers

Symbol(s)

PAFAH1B3;

External IDs

OMIM: 603074 MGI: 108414 HomoloGene: 1933

Gene ontology
Molecular Function:	• 1-alkyl-2-acetylglycerophosphocholine esterase activity • protein binding • hydrolase activity, acting on ester bonds
Cellular Component:	• soluble fraction • cytoplasm
Biological Process:	• spermatogenesis • nervous system development • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002573 (mRNA)
NP_002564 (protein)

NM_008776 (mRNA)
NP_032802 (protein)

Location

Chr 19: 47.49 - 47.5 Mb

Chr 7: 25 - 25.01 Mb

Pubmed search

[1]

[2]

Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa, also known as PAFAH1B3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa.

[edit] Further reading

Adachi H, Tsujimoto M, Hattori M, et al. (1995). "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues.". Biochem. Biophys. Res. Commun. 214 (1): 180–7. doi:10.1006/bbrc.1995.2272. PMID 7669037.
Moro F, Arrigo G, Fogli A, et al. (1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively.". Genomics 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
Sweeney KJ, Clark GD, Prokscha A, et al. (2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development.". Mech. Dev. 92 (2): 263–71. PMID 10727864.
Sheffield PJ, McMullen TW, Li J, et al. (2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib.". Protein Eng. 14 (7): 513–9. PMID 11522926.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems.". Biochem. Biophys. Res. Commun. 314 (2): 396–402. PMID 14733918.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.