PAFAH1B2

From Wikipedia, the free encyclopedia

Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa

PDB rendering based on 1fxw.

Available structures: 1fxw, 1vyh

Identifiers

Symbol(s)

PAFAH1B2;

External IDs

OMIM: 602508 MGI: 108415 HomoloGene: 1932

Gene ontology
Molecular Function:	• 1-alkyl-2-acetylglycerophosphocholine esterase activity • hydrolase activity, acting on ester bonds
Cellular Component:	• cytoplasm
Biological Process:	• spermatogenesis • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002572 (mRNA)
NP_002563 (protein)

NM_008775 (mRNA)
NP_032801 (protein)

Location

Chr 11: 116.53 - 116.54 Mb

Chr 9: 45.72 - 45.74 Mb

Pubmed search

[1]

[2]

Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa, also known as PAFAH1B2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa.

[edit] Further reading

Albrecht U, Abu-Issa R, Rätz B, et al. (1997). "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor.". Dev. Biol. 180 (2): 579-93. doi:10.1006/dbio.1996.0330. PMID 8954729.
Adachi H, Tsujimoto M, Hattori M, et al. (1997). "Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I).". Biochem. Biophys. Res. Commun. 233 (1): 10-3. doi:10.1006/bbrc.1997.6383. PMID 9144386.
Moro F, Arrigo G, Fogli A, et al. (1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively.". Genomics 51 (1): 157-9. doi:10.1006/geno.1998.5322. PMID 9693049.
Sweeney KJ, Clark GD, Prokscha A, et al. (2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development.". Mech. Dev. 92 (2): 263-71. PMID 10727864.
Sheffield PJ, McMullen TW, Li J, et al. (2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib.". Protein Eng. 14 (7): 513-9. PMID 11522926.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311-26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876-84. doi:10.1002/pmic.200401239. PMID 16130169.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Hasstedt SJ, Scott BT, Rosendaal FR, et al. (2007). "Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample.". Thromb. Haemost. 98 (3): 587-92. PMID 17849047.