PACSIN2

From Wikipedia, the free encyclopedia

Protein kinase C and casein kinase substrate in neurons 2

Identifiers

External IDs

OMIM: 604960 MGI: 1345153 HomoloGene: 21414

Gene ontology
Molecular Function:	• transporter activity • cytoskeletal protein binding
Cellular Component:	• cytoplasm • cytosol
Biological Process:	• intracellular protein transport • endocytosis • actin cytoskeleton organization and biogenesis • negative regulation of endocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007229 (mRNA)
NP_009160 (protein)

NM_011862 (mRNA)
NP_035992 (protein)

Location

Chr 22: 41.6 - 41.74 Mb

Chr 15: 83.2 - 83.29 Mb

Pubmed search

[1]

[2]

Protein kinase C and casein kinase substrate in neurons 2, also known as PACSIN2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PACSIN2 protein kinase C and casein kinase substrate in neurons 2.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Ritter B, Modregger J, Paulsson M, Plomann M (1999). "PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins.". FEBS Lett. 454 (3): 356-62. PMID 10431838.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Modregger J, Ritter B, Witter B, et al. (2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.". J. Cell. Sci. 113 Pt 24: 4511-21. PMID 11082044.
Sumoy L, Pluvinet R, Andreu N, et al. (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.". Gene 262 (1-2): 199-205. PMID 11179684.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Ghadimi MP, Sanzenbacher R, Thiede B, et al. (2002). "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178).". FEBS Lett. 519 (1-3): 50-8. PMID 12023017.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Kessels MM, Dong J, Leibig W, et al. (2006). "Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network.". J. Cell. Sci. 119 (Pt 8): 1504-16. doi:10.1242/jcs.02877. PMID 16551695.
Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.". J. Biol. Chem. 281 (27): 18753-62. doi:10.1074/jbc.M602452200. PMID 16627472.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.