PABPC3

From Wikipedia, the free encyclopedia

Poly(A) binding protein, cytoplasmic 3

PDB rendering based on 1g9l.

Available structures: 1g9l, 1jgn, 1jh4, 2d9p

Identifiers

Symbol(s)

PABPC3; PABP3; PABPL3

External IDs

OMIM: 604680 HomoloGene: 84870

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • poly(A) binding
Cellular Component:	• cytoplasm
Biological Process:	• mRNA metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_030979 (mRNA)
NP_112241 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 13: 24.57 - 24.57 Mb

n/a

Pubmed search

[1]

n/a

Poly(A) binding protein, cytoplasmic 3, also known as PABPC3, is a human gene.^[1]

Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3.

[edit] Further reading

Marques AC, Dupanloup I, Vinckenbosch N, et al. (2006). "Emergence of young human genes after a burst of retroposition in primates.". PLoS Biol. 3 (11): e357. doi:10.1371/journal.pbio.0030357. PMID 16201836.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Féral C, Guellaën G, Pawlak A (2002). "Human testis expresses a specific poly(A)-binding protein.". Nucleic Acids Res. 29 (9): 1872-83. PMID 11328870.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Féral C, Mattéi MG, Pawlak A, Guellaën G (1999). "Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes.". Hum. Genet. 105 (4): 347-53. PMID 10543404.
Hoshino S, Imai M, Kobayashi T, et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.". J. Biol. Chem. 274 (24): 16677-80. PMID 10358005.
Morris CM, Bodger MP (1993). "Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization.". Genomics 15 (1): 209-11. doi:10.1006/geno.1993.1037. PMID 8432538.