PABPC1

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Poly(A) binding protein, cytoplasmic 1
PDB rendering based on 1cvj.
Available structures: 1cvj, 1g9l, 1jgn, 1jh4, 2d9p
Identifiers
Symbol(s) PABPC1; PABP1; PAB1; PABP; PABPC2; PABPL1
External IDs OMIM: 604679 MGI: 1349722 HomoloGene: 37638
Orthologs
Human Mouse
Entrez 26986 18458


Refseq NM_002568 (mRNA)
NP_002559 (protein)		 NM_008774 (mRNA)
NP_032800 (protein)
Pubmed search [1] [2]

Poly(A) binding protein, cytoplasmic 1, also known as PABPC1, is a human gene.

The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4; MIM 603407), and PABP3 (PABPC3; MIM 604680). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.[supplied by OMIM][1]

[edit] References

  1. ^ Entrez Gene: PABPC1 poly(A) binding protein, cytoplasmic 1.

[edit] Further reading

  • Grange T, de Sa CM, Oddos J, Pictet R (1987). "Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif.". Nucleic Acids Res. 15 (12): 4771–87. PMID 2885805. 
  • Görlach M, Burd CG, Dreyfuss G (1994). "The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity.". Exp. Cell Res. 211 (2): 400–7. doi:10.1006/excr.1994.1104. PMID 7908267. 
  • Campbell LH, Borg KT, Haines JK, et al. (1994). "Human immunodeficiency virus type 1 Rev is required in vivo for binding of poly(A)-binding protein to Rev-dependent RNAs.". J. Virol. 68 (9): 5433–8. PMID 8057425. 
  • Huang Y, Carmichael GG (1996). "Role of polyadenylation in nucleocytoplasmic transport of mRNA.". Mol. Cell. Biol. 16 (4): 1534–42. PMID 8657127. 
  • Craig AW, Haghighat A, Yu AT, Sonenberg N (1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.". Nature 392 (6675): 520–3. doi:10.1038/33198. PMID 9548260. 
  • Afonina E, Stauber R, Pavlakis GN (1998). "The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm.". J. Biol. Chem. 273 (21): 13015–21. PMID 9582337. 
  • Imataka H, Gradi A, Sonenberg N (1999). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMID 9857202. 
  • Hornstein E, Git A, Braunstein I, et al. (1999). "The expression of poly(A)-binding protein gene is translationally regulated in a growth-dependent fashion through a 5'-terminal oligopyrimidine tract motif.". J. Biol. Chem. 274 (3): 1708–14. PMID 9880551. 
  • Laroia G, Cuesta R, Brewer G, Schneider RJ (1999). "Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.". Science 284 (5413): 499–502. PMID 10205060. 
  • Hoshino S, Imai M, Kobayashi T, et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.". J. Biol. Chem. 274 (24): 16677–80. PMID 10358005. 
  • Deo RC, Bonanno JB, Sonenberg N, Burley SK (1999). "Recognition of polyadenylate RNA by the poly(A)-binding protein.". Cell 98 (6): 835–45. PMID 10499800. 
  • Féral C, Mattéi MG, Pawlak A, Guellaën G (1999). "Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes.". Hum. Genet. 105 (4): 347–53. PMID 10543404. 
  • Grosset C, Chen CY, Xu N, et al. (2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.". Cell 103 (1): 29–40. PMID 11051545. 
  • Khaleghpour K, Svitkin YV, Craig AW, et al. (2001). "Translational repression by a novel partner of human poly(A) binding protein, Paip2.". Mol. Cell 7 (1): 205–16. PMID 11172725. 
  • Bushell M, Wood W, Carpenter G, et al. (2001). "Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages.". J. Biol. Chem. 276 (26): 23922–8. doi:10.1074/jbc.M100384200. PMID 11274152. 
  • Féral C, Guellaën G, Pawlak A (2002). "Human testis expresses a specific poly(A)-binding protein.". Nucleic Acids Res. 29 (9): 1872–83. PMID 11328870. 
  • Khaleghpour K, Kahvejian A, De Crescenzo G, et al. (2001). "Dual interactions of the translational repressor Paip2 with poly(A) binding protein.". Mol. Cell. Biol. 21 (15): 5200–13. doi:10.1128/MCB.21.15.5200-5213.2001. PMID 11438674. 
  • Woods AJ, Roberts MS, Choudhary J, et al. (2002). "Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells.". J. Biol. Chem. 277 (8): 6428–37. doi:10.1074/jbc.M109446200. PMID 11704675. 
  • Lee J, Bedford MT (2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.". EMBO Rep. 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. PMID 11850402. 
  • Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638. 
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