PA2G4

From Wikipedia, the free encyclopedia

Proliferation-associated 2G4, 38kDa

Identifiers

PA2G4; EBP1; HG4-1; p38-2G4

External IDs

OMIM: 602145 MGI: 894684 HomoloGene: 4513

Gene ontology
Molecular Function:	• transcription factor activity • RNA binding • methionyl aminopeptidase activity • protein binding • metalloexopeptidase activity • hydrolase activity • cobalt ion binding
Cellular Component:	• nucleus • ribonucleoprotein complex
Biological Process:	• transcription • rRNA processing • regulation of translation • proteolysis • cell cycle arrest • cell proliferation • negative regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006191 (mRNA)
NP_006182 (protein)

NM_011119 (mRNA)
NP_035249 (protein)

Location

Chr 12: 54.78 - 54.79 Mb

n/a

Pubmed search

[1]

[2]

Proliferation-associated 2G4, 38kDa, also known as PA2G4, is a human gene.

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.^[1]

[edit] References

^ Entrez Gene: PA2G4 proliferation-associated 2G4, 38kDa.

[edit] Further reading

Radomski N, Jost E (1995). "Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle.". Exp. Cell Res. 220 (2): 434–45. doi:10.1006/excr.1995.1335. PMID 7556453.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Lamartine J, Seri M, Cinti R, et al. (1997). "Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4.". Cytogenet. Cell Genet. 78 (1): 31–5. PMID 9345902.
Froesch BA, Takayama S, Reed JC (1998). "BAG-1L protein enhances androgen receptor function.". J. Biol. Chem. 273 (19): 11660–6. PMID 9565586.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
Yoo JY, Wang XW, Rishi AK, et al. (2000). "Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin.". Br. J. Cancer 82 (3): 683–90. doi:10.1054/bjoc.1999.0981. PMID 10682683.
Lessor TJ, Yoo JY, Xia X, et al. (2000). "Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines.". J. Cell. Physiol. 183 (3): 321–9. doi:10.1002/(SICI)1097-4652(200006)183:3<321::AID-JCP4>3.0.CO;2-O. PMID 10797306.
Xia X, Cheng A, Lessor T, et al. (2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation.". J. Cell. Physiol. 187 (2): 209–17. doi:10.1002/jcp.1075. PMID 11268000.
Lessor TJ, Hamburger AW (2001). "Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.". Mol. Cell. Endocrinol. 175 (1-2): 185–91. PMID 11325528.
Xia X, Lessor TJ, Zhang Y, et al. (2001). "Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein.". Biochem. Biophys. Res. Commun. 289 (1): 240–4. doi:10.1006/bbrc.2001.5942. PMID 11708806.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Zhang Y, Fondell JD, Wang Q, et al. (2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1.". Oncogene 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang Y, Woodford N, Xia X, Hamburger AW (2003). "Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases.". Nucleic Acids Res. 31 (8): 2168–77. PMID 12682367.
Squatrito M, Mancino M, Donzelli M, et al. (2004). "EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.". Oncogene 23 (25): 4454–65. doi:10.1038/sj.onc.1207579. PMID 15064750.
Zhang Y, Hamburger AW (2004). "Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription.". J. Biol. Chem. 279 (25): 26126–33. doi:10.1074/jbc.M314305200. PMID 15073182.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang Y, Hamburger AW (2005). "Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling.". Br. J. Cancer 92 (1): 140–6. doi:10.1038/sj.bjc.6602257. PMID 15583694.