P2RY2

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Purinergic receptor P2Y, G-protein coupled, 2
Identifiers
Symbol(s) P2RY2; HP2U; MGC20088; MGC40010; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R
External IDs OMIM: 600041 MGI: 105107 HomoloGene: 1927
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5029 18442
Ensembl ENSG00000175591 ENSMUSG00000032860
Uniprot P41231 Q3U185
Refseq NM_002564 (mRNA)
NP_002555 (protein)		 NM_008773 (mRNA)
NP_032799 (protein)
Location Chr 11: 72.61 - 72.63 Mb Chr 7: 100.87 - 100.89 Mb
Pubmed search [1] [2]

Purinergic receptor P2Y, G-protein coupled, 2, also known as P2RY2, is a human gene.

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.[1]

[edit] See also

[edit] References

  1. ^ Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2.

[edit] Further reading

  • Tokuyama Y, Hara M, Jones EM, et al. (1995). "Cloning of rat and mouse P2Y purinoceptors.". Biochem. Biophys. Res. Commun. 211 (1): 211–8. doi:10.1006/bbrc.1995.1798. PMID 7779087. 
  • Parr CE, Sullivan DM, Paradiso AM, et al. (1995). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 13067. PMID 7809171. 
  • Parr CE, Sullivan DM, Paradiso AM, et al. (1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3275–9. PMID 8159738. 
  • Erb L, Lustig KD, Sullivan DM, et al. (1993). "Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10449–53. PMID 8248130. 
  • Dasari VR, Sandhu AK, Mills DC, et al. (1996). "Mapping of the P2U purinergic receptor gene to human chromosome 11q 13.5-14.1.". Somat. Cell Mol. Genet. 22 (1): 75–9. PMID 8643996. 
  • Sullivan DM, Erb L, Anglade E, et al. (1997). "Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells.". J. Neurosci. Res. 49 (1): 43–52. PMID 9211988. 
  • Somers GR, Hammet F, Woollatt E, et al. (1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family.". Genomics 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708. 
  • Bogdanov Y, Rubino A, Burnstock G (1998). "Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart.". Life Sci. 62 (8): 697–703. PMID 9489506. 
  • Jin J, Dasari VR, Sistare FD, Kunapuli SP (1998). "Distribution of P2Y receptor subtypes on haematopoietic cells.". Br. J. Pharmacol. 123 (5): 789–94. doi:10.1038/sj.bjp.0701665. PMID 9535005. 
  • Tai CJ, Kang SK, Cheng KW, et al. (2000). "Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells.". J. Clin. Endocrinol. Metab. 85 (4): 1591–7. PMID 10770202. 
  • Erb L, Liu J, Ockerhausen J, et al. (2001). "An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction.". J. Cell Biol. 153 (3): 491–501. PMID 11331301. 
  • Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.". Biochim. Biophys. Acta 1521 (1-3): 107–19. PMID 11690642. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.". J. Invest. Dermatol. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858. 
  • Schafer R, Sedehizade F, Welte T, Reiser G (2003). "ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2): L376–85. doi:10.1152/ajplung.00447.2002. PMID 12691958. 
  • Seye CI, Yu N, Jain R, et al. (2003). "The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells.". J. Biol. Chem. 278 (27): 24960–5. doi:10.1074/jbc.M301439200. PMID 12714597. 
  • Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007–15. PMID 12787128. 
  • Greig AV, Linge C, Healy V, et al. (2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.". J. Invest. Dermatol. 121 (2): 315–27. doi:10.1046/j.1523-1747.2003.12379.x. PMID 12880424. 
  • Meshki J, Tuluc F, Bredetean O, et al. (2004). "Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor.". Am. J. Physiol., Cell Physiol. 286 (2): C264–71. doi:10.1152/ajpcell.00287.2003. PMID 14613890. 
  • Haserück N, Erl W, Pandey D, et al. (2004). "The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors.". Blood 103 (7): 2585–92. doi:10.1182/blood-2003-04-1127. PMID 14645014. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened